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Delivery of drugs through the blood-brain barrier: need for trials.
Lancet Neurol
January 2025
Geriatric Research Education and Clinical Center, Veterans Affairs Puget Sound Health Care System, Seattle, WA 98108, USA; Division of Gerontology and Geriatric Medicine, Department of Medicine, University of Washington School of Medicine, Seattle, WA, USA.
Role of P × receptor during focused ultrasound induced blood brain barrier modulation.
Sci Rep
January 2025
Department of Neurosurgery and Brain Research Institute, Yonsei University College of Medicine, Seoul, Republic of Korea.
Although low-intensity focused ultrasound (LiFUS) with microbubbles is used to temporally open the blood-brain barrier (BBB), the underlying mechanism is not fully understood. This study aimed to analyze BBB-related alterations in the brain microenvironment after LiFUS, with a focus on the involvement of the purinergic P × receptor. Sprague-Dawley rats were sonicated with LiFUS at 0.
View Article and Find Full Text PDFCharacterization of focused ultrasound blood-brain barrier disruption effect on inflammation as a function of treatment parameters.
Biomed Pharmacother
January 2025
Department of Radiology, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, United States. Electronic address:
The technology of focused ultrasound-mediated disruption of the blood-brain barrier (FUS-BBB opening) has now been used in over 20 Phase 1 clinical trials to validate the safety and feasibility of BBB opening for drug delivery in patients with brain tumors and neurodegenerative diseases. The primary treatment parameters, FUS intensity and microbubble dose, are chosen to balance sufficient BBB disruption to achieve drug delivery against potential acute vessel damage leading to microhemorrhage. However, other safety considerations due to second order effects caused by BBB disruption, such as inflammation and alteration of neurovascular function, are only beginning to be understood.
View Article and Find Full Text PDFA comparative study of experimental and simulated ultrasound beam propagation through cranial bones.
Phys Med Biol
January 2025
Department of Medical Physics and Biomedical Engineering, University College London, London WC1E 6BT, United Kingdom.
Transcranial ultrasound is used in a variety of treatments, including neuromodulation, opening the blood-brain barrier, and high intensity focused ultrasound therapies. To ensure safety and efficacy of these treatments, numerical simulations of the ultrasound field within the brain are used for treatment planning and evaluation. This study investigates the accuracy of numerical modelling of the propagation of focused ultrasound through cranial bones.
View Article and Find Full Text PDFReversible Ca signaling and enhanced paracellular transport in endothelial monolayer induced by acoustic bubbles and targeted microbeads.
Ultrason Sonochem
January 2025
Institute of Biomedical Engineering, Shenzhen Bay Laboratory, Shenzhen, China. Electronic address:
Article Synopsis
- Ultrasound combined with microbubble technology effectively opens the blood-brain barrier, allowing targeted drug delivery, but the underlying mechanisms, particularly regarding calcium signaling, need further exploration.
- Research showed that microbubbles create strong calcium responses and cell poration, while integrin-targeted microbeads lead to temporary calcium changes without damaging the cell membrane, highlighting different bioeffects in brain endothelial cells.
- The study also found that both microbubbles and microbeads enhance the permeability of endothelial cells for larger molecules, indicating potential improvements in drug delivery methods through better understanding of calcium signaling and cell junction dynamics.
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