AI Article Synopsis
- Aminoglycosides are effective for treating serious lung infections, but detailed studies on how well they penetrate lung fluid are limited.
- The research analyzed data from eight studies and found that aminoglycoside penetration into lung fluid varies, with ELF concentrations ranging from 50% to 100% of those in plasma.
- While the peak concentrations of aminoglycosides in lung epithelial lining fluid were lower than expected, their overall exposure remained moderately high, indicating a complex relationship between the drug and lung tissue.
Article Abstract
Aminoglycosides are important treatment options for serious lung infections, but modeling analyses to quantify their human lung epithelial lining fluid (ELF) penetration are lacking. We estimated the extent and rate of penetration for five aminoglycosides via population pharmacokinetics from eight published studies. The area under the curve in ELF vs plasma ranged from 50% to 100% and equilibration half-lives from 0.61 to 5.80 h, indicating extensive system hysteresis. Aminoglycoside ELF peak concentrations were blunted, but overall exposures were moderately high.
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Source |
|---|---|
| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC10848756 | PMC |
| http://dx.doi.org/10.1128/aac.01393-23 | DOI Listing |
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