Download full-text PDF |
Source |
|---|---|
| http://dx.doi.org/10.1016/j.asjsur.2023.12.140 | DOI Listing |
Publication Analysis
Top Keywords
Similar Publications
Targeting Siglec-15 mediates mitochondrial retrograde regulation of cervical cancer development.
Tissue Cell
December 2024
Department of Gynecology, Yantai Yuhuangding Hospital, Shandong University, Yantai, Shandong 264000, China. Electronic address:
Cervical cancer (CCA) is the predominant cause of fatalities from gynecologic malignancies, with metastasis responsible for 80 % of cancer-related mortalities. This study preliminarily examined the involvement of Sialic Acid Binding Ig Like Lectin 15 (Siglec-15) in the development of CCA and its probable mechanisms. We assessed the capacity of Siglec-15 to modulate CCA progression by establishing knockdown and overexpression Siglec-15 cell lines, supplemented with animal models, using both in vivo and in vitro dual investigations.
View Article and Find Full Text PDFSiglec15 in blood system diseases: from bench to bedside.
Front Immunol
December 2024
Clinical Laboratory Medicine Centre, Inner Mongolia Autonomous Region People's Hospital, Hohhot, Inner Mongolia, China.
Inhibiting the PD-1/PD-L1 pathway using immunomodulators has demonstrated promising outcomes in clinics. Immunomodulators can effectively target immune checkpoints with a strong preference for the tumor microenvironment (TME). Besides, immunomodulators specifically target the recently discovered inhibitory immune checkpoint, sialic acid-binding immunoglobulin-like lectin (Siglec-15).
View Article and Find Full Text PDFExpression of SIGLEC15 correlates with tumor immune infiltration, molecular subtypes, and breast cancer progression.
PLoS One
November 2024
Department of Pathology, Zhongnan Hospital of Wuhan University, Wuhan, P. R. China.
Breast cancer (BRCA) is among the most prevalent cancers and is responsible for numerous patient fatalities. Immunotherapy has emerged as a promising approach to cancer treatment. Recent studies have identified Siglec-15 as a novel immune target that plays a crucial role in tumor immune evasion, suggesting its potential significance in BRCA.
View Article and Find Full Text PDFSiglec-15 as a potential molecule involved in osteoclast differentiation and bone metabolism.
Heliyon
November 2024
Department of Orthodontics, Medical Center of Stomatology, The Second Xiangya Hospital, Central South University, Furong District, Changsha, Hunan, 410011, China.
Sialic acid-binding immunoglobulin-like lectin 15 (Siglec-15) is a well-conserved type I transmembrane protein of the Siglecs family, distributed in macrophages and dendritic cells in the human spleen and lymph nodes. As an immune receptor, Siglec-15 is expressed in almost all branches of the spinal cord. Siglec-15 participates in the metabolism of the skeleton by regulating osteoclast activity and differentiation and has an influential role in dynamic bone remodelling.
View Article and Find Full Text PDFDifferential expression of ST6GALNAC1 and ST6GALNAC2 and their clinical relevance to colorectal cancer progression.
PLoS One
September 2024
School of Life and Medical Sciences, University of Hertfordshire, Hatfield, United Kingdom.
Colorectal cancer (CRC) has become a significant global health concern and ranks among the leading causes of morbidity and mortality worldwide. Due to its malignant nature, current immunotherapeutic treatments are used to tackle this issue. However, not all patients respond positively to treatment, thereby limiting clinical effectiveness and requiring the identification of novel therapeutic targets to optimise current strategies.
View Article and Find Full Text PDFWant AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!