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High-filler content electrospun fibers from biodegradable polymers and hydroxyapatite: Toward improved scaffolds for tissue engineering.
Polim Med
December 2024
Department of Polymer Engineering and Technology, Faculty of Chemistry, Wroclaw University of Science and Technology, Poland.
Background: One of the key challenges in tissue engineering area is the creation of biocompatible scaffolds that support cell growth and mimic the structural and mechanical properties of native tissues. Among various materials used for scaffold fabrication, composite materials based on biodegradable polymers reinforced with bioactive inorganic fillers have attracted significant attention due to their properties. One of the important problems with the preparation of composite electrospun fibers is the low filler content in the fiber.
View Article and Find Full Text PDFAdvanced Biomaterials for Lacrimal Tissue Engineering: A Review.
Materials (Basel)
November 2024
Faculty of Dental Medicine and Oral Health Sciences, McGill University, Montreal, QC H3A 1G1, Canada.
The lacrimal gland (LG) is vital for ocular health, producing tears that lubricate and protect the eye. Dysfunction of the LG leads to aqueous-deficient dry eye disease (DED), significantly impacting quality of life. Current treatments mainly address symptoms rather than the underlying LG dysfunction, highlighting the need for regenerative therapies.
View Article and Find Full Text PDFPiezoelectric nanocomposite electrospun dressings: Tailoring mechanics for scar-free wound recovery.
Biomater Adv
February 2025
Research Center for Wound Repair and Tissue Regeneration, Medical Innovation Research Department, Chinese PLA General Hospital, Beijing 100048, China; Research Unit of Trauma Care, Tissue Repair and Regeneration, Chinese Academy of Medical Sciences, 2019RU051, Beijing 100048, China. Electronic address:
Rational wound management and enhancing healing quality are critical in clinical practice. Electrical stimulation therapy (EST) has emerged as a valuable adjunctive treatment due to its safety and cost-effectiveness. Integrating piezoelectric materials into dressings offers a way to miniaturize and personalize electrotherapy, enhancing convenience.
View Article and Find Full Text PDFBiomimetic periosteum-bone scaffolds with codelivery of BMP-2 and PDGF-BB for skull repair.
Bone
January 2025
Department of Orthopedics, The First Affiliated Hospital of Soochow University, Suzhou, Jiangsu 215300, China. Electronic address:
Tissue engineering employs the use of bioactive materials to facilitate the filling and acceleration of bone defect healing, thereby introducing novel concepts to the field of in situ bone repair. Some studies have shown that periosteum plays an important role in bone regeneration and repair. In this study, biomimetic periosteum-bone scaffolds were prepared by depositing poly-L-lactic acid (PLLA) electrospun fibers on the surface of the gelatin/chitosan cryogel to mimic the bone and periosteum structure, respectively.
View Article and Find Full Text PDFNanofibrous 3D scaffolds capable of individually controlled BMP and FGF release for the regulation of bone regeneration.
Acta Biomater
December 2024
Department of Biomedical Engineering, University of Michigan, Ann Arbor, MI 48109, USA; Department of Biologic and Materials Sciences, University of Michigan, Ann Arbor, MI 48109, USA; Macromolecular Science and Engineering Center, University of Michigan, Ann Arbor, MI 48109, USA; Department of Materials Science and Engineering, University of Michigan, Ann Arbor, MI 48109, USA. Electronic address:
The current clinical applications of bone morphogenetic proteins (BMPs) are limited to only a few specific indications. Locally controlled delivery of combinations of growth factors can be a promising strategy to improve BMP-based bone repair. However, the success of this approach requires the development of an effective release system and the correct choice of growth factors capable of enhancing BMP activity.
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