Background: No reports have compared the clinical therapeutic efficacy of fluconazole and itraconazole in canine Malassezia dermatitis.
Objectives: The study aimed to compare the clinical therapeutic efficacy of fluconazole and itraconazole and to evaluate the adverse effects of fluconazole in canine Malassezia dermatitis.
Animals: Sixty-one client-owned dogs with Malassezia dermatitis.
Materials And Methods: The enrolled animals were randomly divided into groups receiving 5 mg/kg fluconazole (5FZ), 10 mg/kg fluconazole (10FZ) or 5 mg/kg itraconazole (5IZ). The drugs were orally administered once daily for 28 days. Cytological examination, clinical index score (CIS), pruritus Visual Analog Scale (PVAS) evaluation and blood analysis (for 5FZ only) were performed on Day (D)0, D14 and D28.
Results: On D14, significant reductions in mean yeast count (MYC), CIS and PVAS were observed in the 5FZ (n = 20, p < 0.01), 10FZ (n = 17, p < 0.01) and 5IZ (n = 16, p < 0.05) groups. In all three groups, a significant reduction (p < 0.001) in MYC, CIS and PVAS expression was observed on D28. There was no significant difference in the percentage reduction of MYC, CIS and PVAS among the groups. Moreover, there was a significant difference (p < 0.05) in each group between D14 and D28, except for the percentage reduction in MYC in the 10FZ and 5IZ groups. No adverse effects of fluconazole were observed in the 5FZ or 10FZ groups.
Conclusions And Clinical Relevance: This study indicates that 5FZ and 10FZ are as effective as itraconazole in canine Malassezia dermatitis.
Download full-text PDF |
Source |
|---|---|
| http://dx.doi.org/10.1111/vde.13233 | DOI Listing |
Publication Analysis
Top Keywords
Similar Publications
Efficacy of liposomal amphotericin B in treating fungal meningitis in AIDS Patients: A review article.
Egypt J Immunol
January 2025
Department of Microbiology and Infection Prevention and Control Unit, Theodor Bilharz Research Institute, Giza 12411, Egypt.
Cryptococcal meningitis is an alarming fungal infection that usually affects the meninges surrounding the brain and spinal cord. The causative organism is Cryptococcus neoformans. Although this infection can occur in normal individuals, it is more often seen in patients with human immunodeficiency virus/acquired immunodeficiency syndrome.
View Article and Find Full Text PDFPerspectives on the Use of Echinocandins in the Neonatal Intensive Care Unit.
Antibiotics (Basel)
December 2024
Neonatal Intensive Care Unit, School of Medicine, University of Ioannina, 45500 Ioannina, Greece.
The neonatal intensive care unit (NICU) population, especially low birth weight and critically ill neonates, is at risk of invasive infections, which are associated with high mortality rates and unfavorable long-term outcomes. The timely initiation of an appropriate antifungal treatment has been demonstrated to enhance the prognosis. Factors that should be considered in the choice of an antifungal agent include the causative strain, the presence and location of deep tissue infection, any previous use of antifungal prophylaxis, and the presence of implanted devices.
View Article and Find Full Text PDFEllagic Acid Potentiates the Inhibitory Effects of Fluconazole Against .
Antibiotics (Basel)
December 2024
Centro de Ciências da Saúde, Universidade Federal do Maranhão, São Luís 65080-805, MA, Brazil.
: Antifungal resistance to azoles, coupled with the increasing prevalence of infections, represents a significant public health challenge and has driven the search for new natural compounds that can act as alternatives or adjuvants to the current antifungals. Ellagic acid (EA) has demonstrated antifungal activity; however, its effects are not fully understood. In this study, we investigated the in vitro anti- activity of EA and its ability to potentiate the effects of fluconazole (FLZ) on : The Minimum Inhibitory Concentration (MIC) of EA was determined by broth microdilution and its interaction with FLZ was assessed using a checkerboard assay.
View Article and Find Full Text PDFCharacterization and analysis of the bioactivity of the Piper rivinoides Kunth essential oil and its components myristicin and elemicin, against opportunistic fungal pathogens.
Microb Pathog
December 2024
Universidade Regional Do Cariri - URCA, Rua Cel. Antônio Luiz, 1161 - Pimenta, Crato, CE, Brazil.
Candidiasis is an infectious disease caused by some fungi of the genus Candida. In Brazil, the incidence rate is higher than in European countries and the United States, and health problems occur mainly due to the virulence factors of the fungi, which have made treatment with commercial drugs difficult. Considering the context, plants rich in phenolic compounds, such as those of the genus Piper, have been studied due to their antimicrobial properties.
View Article and Find Full Text PDFZerumbone disrupts mixed biofilms of and on acrylic resin.
Biofouling
January 2025
Laboratory of Applied Microbiology Department of Dental Materials and Prosthodontics, São Paulo State University (UNESP), School of Dentistry, Araraquara, SP, Brazil.
The efficacy of Zerumbone (ZER) against mixed biofilms of fluconazole-resistant (ATCC 96901) and (UA159) was evaluated. Biofilms were cultivated on acrylic resin specimens for 48 h, with alternating supplementation of glucose and sucrose. ZER's ability to inhibit biofilm formation (pre-treatment) and eradicate mature biofilms (post-treatment) was assessed.
View Article and Find Full Text PDFWant AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!