Pigs can be an important model for preclinical biological research, including neurological diseases such as Alcohol Use Disorder. Such research often involves longitudinal assessment of changes in motor coordination as the disease or disorder progresses. Current motor coordination tests in pigs are derived from behavioral assessments in rodents and lack critical aspects of face and construct validity. While such tests may permit for the comparison of experimental results to rodents, a lack of validation studies of such tests in the pig itself may preclude the drawing of meaningful conclusions. Here, we present a novel, optimized, and reliable horizontal ladder test (HLT) test protocol for evaluating motor coordination in pigs and an initial validation of its construct validity using voluntary alcohol consumption as an experimental manipulation.
Download full-text PDF |
Source |
|---|---|
| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC10760169 | PMC |
| http://dx.doi.org/10.1101/2023.12.13.571517 | DOI Listing |
Publication Analysis
Top Keywords
Similar Publications
The songbird connectome (OSCINE-NET.ORG): structure-function organization beyond the canonical vocal control network.
BMC Neurosci
December 2024
Department of Medicine, The University of Chicago, 5841 S Maryland Ave, Chicago, IL, 60637, USA.
Background: Understanding the neural basis of behavior requires insight into how different brain systems coordinate with each other. Existing connectomes for various species have highlighted brain systems essential to various aspects of behavior, yet their application to complex learned behaviors remains limited. Research on vocal learning in songbirds has extensively focused on the vocal control network, though recent work implicates a variety of circuits in contributing to important aspects of vocal behavior.
View Article and Find Full Text PDFAutophagic signatures in peripheral blood mononuclear cells from Parkinson's disease patients.
Mol Cells
December 2024
Department of Biomedical Sciences, Ajou University School of Medicine, Suwon, Republic of Korea; Department of Brain Science, Ajou University School of Medicine, Suwon, Republic of Korea. Electronic address:
Parkinson's disease (PD) is a progressive neurodegenerative disorder characterized by motor impairments and the accumulation of misfolded α-synuclein. Dysregulation of the autophagy-lysosomal pathway (ALP), responsible for degrading misfolded proteins, has been implicated in PD pathogenesis. However, current diagnostic approaches rely heavily on motor symptoms, which occur due to substantial neurodegeneration, limiting early detection and intervention.
View Article and Find Full Text PDFPilot Study on the Relationship Between Different Lower Limb Raising Velocities and Trunk Muscle Contraction in Active Straight Leg Raise.
J Funct Morphol Kinesiol
December 2024
Department of Physical Therapy, School of Rehabilitation, Biwako Professional University of Rehabilitation, Higashiomi 527-0145, Japan.
Background/objectives: The active straight leg raise requires intricate coordination between the hip, knee, pelvis, and spine. Despite its complexity, limited research has explored the relationship between lower limb raising velocity and trunk muscle motor control during an active straight leg raise in healthy individuals. This study aimed to explore the potential effects of increased lower limb raising velocity on core muscle contractions during active straight leg raises.
View Article and Find Full Text PDFA Qualitative Investigation into the Experiences of Students with Developmental Coordination Disorder (DCD/Dyspraxia) in Higher Education.
Eur J Investig Health Psychol Educ
December 2024
School of Psychology, University of Surrey, Guildford GU2 7XH, UK.
Developmental coordination disorder (DCD/Dyspraxia) is a commonly misunderstood and under-recognized specific learning difficulty (SpLD) in educational settings. This lifelong condition affects fine and gross motor coordination and significantly interferes with many activities of daily living, academic achievement, and employment opportunities. However, most Higher Education Institutions (HEIs) are unaware of its prevalence within their context, even though 5% of the general population have DCD and the enrolment of students in UK Higher Education with a known disability has increased by 42.
View Article and Find Full Text PDFUnraveling EEG correlates of unimanual finger movements: insights from non-repetitive flexion and extension tasks.
J Neuroeng Rehabil
December 2024
Laboratory for Neuro- & Psychophysiology, Department of Neurosciences, KU Leuven, Leuven, Belgium.
Background: The loss of finger control in individuals with neuromuscular disorders significantly impacts their quality of life. Electroencephalography (EEG)-based brain-computer interfaces that actuate neuroprostheses directly via decoded motor intentions can help restore lost finger mobility. However, the extent to which finger movements exhibit distinct and decodable EEG correlates remains unresolved.
View Article and Find Full Text PDFWant AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!