AI Article Synopsis
- Homogenous catalysis is important for producing bulk and fine chemicals, with phosphine ligands like tricyclohexylphosphine (CYTOP® 366) playing a vital role in this process.
- In designing the synthesis of these ligands, factors such as safety, yield, quality, cost, and available technologies must be weighed, especially for large-scale production.
- The report details the chosen synthetic route for tricyclohexylphosphine, examining both the successes of this pathway and the failures of traditional hydrophosphination methods through computational calculations.
Article Abstract
Homogenous catalysis is an essential tool within the commercial manufacture of bulk and fine chemicals. Within this, phosphine ligands, such as tricyclohexylphosphine, otherwise known as CYTOP® 366, are a crucial component. When designing a pathway to your ligand of choice, some key considerations include safety, yield and quality, but at commercial volumes we must also balance cost and consider the technologies readily available. Herein, we report the synthetic route that was chosen to manufacture tricyclohexylphosphine at commercial scale. We also consider, with the use of computational calculations, why traditional hydrophosphination methods failed, where the selected pathway succeeded.
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| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC11164020 | PMC |
| http://dx.doi.org/10.1002/open.202300264 | DOI Listing |
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