AI Article Synopsis

  • Bacteria-associated infections and thrombosis, especially from catheters, pose serious health risks, prompting research into better coatings for medical devices.
  • The study introduces a new multifunctional coating made from heparin sodium and organosilicon quaternary ammonium surfactant that can adapt to different shapes and surfaces of catheters.
  • This innovative coating not only significantly reduces thrombus adhesion by 60% but also shows over 97% antibacterial effectiveness, and has been tested on rabbits to confirm its ability to prevent infections during catheter use.

Article Abstract

Bacteria-associated infections and thrombosis, particularly catheter-related bloodstream infections and catheter-related thrombosis, are life-threatening complications. Herein, we utilize a concise assembly of heparin sodium with organosilicon quaternary ammonium surfactant to fabricate a multifunctional coating complex. In contrast to conventional one-time coatings, the complex attaches to medical devices with arbitrary shapes and compositions through a facile dipping process and further forms robust coatings to treat catheter-related bloodstream infections and thrombosis simultaneously. Through their robustness and adaptively dissociation, coatings not only exhibit good stability under extreme conditions but also significantly reduce thrombus adhesion by 60%, and shows broad-spectrum antibacterial activity ( > 97%) in vitro and in vivo. Furthermore, an ex vivo rabbit model verifies that the coated catheter has the potential to prevent catheter-related bacteremia during implantation. This substrate-independent and portable long-lasting multifunctional coating can be employed to meet the increasing clinical demands for combating catheter-related bloodstream infections and thrombosis.

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Source
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC10761715PMC
http://dx.doi.org/10.1038/s41467-023-44478-3DOI Listing

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