A PHP Error was encountered

Severity: Warning

Message: file_get_contents(https://...@pubfacts.com&api_key=b8daa3ad693db53b1410957c26c9a51b4908&a=1): Failed to open stream: HTTP request failed! HTTP/1.1 429 Too Many Requests

Filename: helpers/my_audit_helper.php

Line Number: 176

Backtrace:

File: /var/www/html/application/helpers/my_audit_helper.php
Line: 176
Function: file_get_contents

File: /var/www/html/application/helpers/my_audit_helper.php
Line: 250
Function: simplexml_load_file_from_url

File: /var/www/html/application/helpers/my_audit_helper.php
Line: 3122
Function: getPubMedXML

File: /var/www/html/application/controllers/Detail.php
Line: 575
Function: pubMedSearch_Global

File: /var/www/html/application/controllers/Detail.php
Line: 489
Function: pubMedGetRelatedKeyword

File: /var/www/html/index.php
Line: 316
Function: require_once

Binding of Per- and Polyfluoroalkyl Substances (PFAS) to Serum Proteins: Implications for Toxicokinetics in Humans. | LitMetric

AI Article Synopsis

  • PFAS (per- and polyfluoroalkyl substances) are persistent chemicals found in humans, linked to health issues like immune problems and cancer.
  • Research shows PFAS bind differently to key blood proteins (HSA and globulins) based on the length of their carbon chains, affecting their transport and toxicity.
  • The varying levels of PFAS binding in individuals highlight the importance of these proteins in studying the health impacts of PFAS exposure.

Article Abstract

Per- and polyfluoroalkyl substances (PFAS) are a diverse class of highly persistent anthropogenic chemicals that are detectable in the serum of most humans. PFAS exposure has been associated with many adverse effects on human health including immunotoxicity, increased risk of certain cancers, and metabolic disruption. PFAS binding to the most abundant blood serum proteins (human serum albumin [HSA] and globulins) is thought to affect transport to active sites, toxicity, and elimination half-lives. However, few studies have investigated the competitive binding of PFAS to these proteins in human serum. Here, we use C18 solid-phase microextraction fibers to measure HSA-water and globulin-water distribution coefficients (, ) for PFAS with carbon chains containing 4 to 13 perfluorinated carbons (η = 4-13) and several functional head-groups. PFAS with η < 7 were highly bound to HSA relative to globulins, whereas PFAS with η ≥ 7 showed a greater propensity for binding to globulins. Experimentally measured and and concentrations of serum proteins successfully predicted the variability in PFAS binding in human serum. We estimated that the unbound fraction of serum PFAS varied by up to a factor of 2.5 among individuals participating in the 2017-2018 U.S. National Health and Nutrition Examination Survey. These results suggest that serum HSA and globulins are important covariates for epidemiological studies aimed at understanding the effects of PFAS exposure.

Download full-text PDF

Source
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC11149785PMC
http://dx.doi.org/10.1021/acs.est.3c07415DOI Listing

Publication Analysis

Top Keywords

serum proteins
12
human serum
12
pfas
11
serum
9
per- polyfluoroalkyl
8
polyfluoroalkyl substances
8
substances pfas
8
pfas exposure
8
pfas binding
8
proteins human
8

Similar Publications

Want AI Summaries of new PubMed Abstracts delivered to your In-box?

Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!