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Passing the torch, a fond farewell.
J Cardiovasc Surg (Torino)
December 2024
Unit of Vascular Surgery, Department of Surgical Sciences, University of Turin, AOU Città della Salute e della Scienza, Turin, Italy -
Passing the Torch forward: Moving beyond EGFR Inhibition in NMIBC Prevention.
Cancer Prev Res (Phila)
January 2025
Department of Oncology, National Taiwan University Hospital, Taipei, Taiwan.
The study by Downs and colleagues targets patients with non-muscle-invasive bladder cancer (NMIBC) to explore secondary/tertiary cancer prevention strategies. Utilizing a "window-of-opportunity" design, erlotinib was evaluated for its effect on EGFR phosphorylation, although the unconventional dosing regimen failed to demonstrate efficacy. New opportunities in NMIBC prevention include targeting FGFR3 mutations with emerging FGFR inhibitors.
View Article and Find Full Text PDFEditorial: Passing the torch: The next chapter for Neurotoxicology and Teratology.
Neurotoxicol Teratol
October 2024
Department of Biomedical Sciences, Florida State University College of Medicine, 1115 W. Call St., Tallahassee, FL 32306, United States of America. Electronic address:
Passing the torch.
J Clin Sleep Med
December 2024
Emory Sleep Center, Emory University, Atlanta, Georgia.
Passing the torch: The ascendance of the glutamatergic synapse in the pathophysiology of schizophrenia.
Biochem Pharmacol
October 2024
Eben S Draper Professor of Psychiatry and Neuroscience Harvard Medical School (Emeritus), McLean Hospital, 115 Mill St, Belmont, MA 02478, United States. Electronic address:
For nearly fifty years, the dopamine hypothesis has dominated our understanding of the pathophysiology of schizophrenia and provided the lone target for drug development. However, with the exception of clozapine, the dopamine D2 receptor antagonizing anti-psychotic drugs have little impact on the negative symptoms and cognitive deficits, aspects of the disorder that robustly predict outcome. Pathologic studies reveal cortical atrophy and wide-spread loss of glutamatergic synaptic spines, unexplained by dopaminergic malfunction.
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