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Filename: controllers/Detail.php
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Function: _error_handler
File: /var/www/html/index.php
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Filename: controllers/Detail.php
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Function: _error_handler
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Filename: controllers/Detail.php
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Function: insertAPISummary
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Function: str_replace
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Function: formatAIDetailSummary
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Filename: controllers/Detail.php
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A suitable drug delivery strategy for metallodrugs is as significant as the strategies adopted for an efficient metallodrug design. In this study, piperlongumine, which is isolated from long pepper, is coordinated with a Ru(II)--cymene moiety to obtain an organoruthenated complex containing the natural product (). The isolated complex shows higher cytotoxicity in MCF-7 breast cancer cells than in THP-1 leukemia and HepG2 liver cancer cells. The IC value of the complex in non-cancerous HEK-239 cells is also almost equal to that in MCF-7 cells. Next, with an aim to modulate the antiproliferative activity of Ru(pip) using a drug delivery strategy, the complex is loaded into mesoporous silica nanorods (), which have a higher surface area than spherical silica nanoparticles. Furthermore, the outer surface of the loaded nanorods is covered with a polydiacetylene-lipid () hybrid bilayer. Given the unique optical properties of polydiacetylene, the PL coating modifies non-fluorescent MSNRs into red-emissive particles (), which can be useful for diagnostic applications. The release profile studies reveal that the ene-yne conjugation in the PL coating ensures the sustained release of the complex from nanoparticles in both physiological and simulated cancer cell media. While Ru(pip) exhibits both necrotic and apoptotic modes of cell death, PL-Ru(pip)@MSNRs preferably induce the apoptotic mode of cell death in MCF-7 and THP-1 cells. Also, the nanoformulation exhibits a higher percentage of cell cycle arrest in the G0/G1 phase than Ru(pip), as measured by flow cytometry analysis. In contrast, the antioxidant potency of the complex is decreased after being loaded into PL-coated silica nanoparticles.
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http://dx.doi.org/10.1039/d3dt02940a | DOI Listing |
Langmuir
December 2024
College of pharmacy, Xinxiang Medical University, Xinxiang 453003, PR China.
Antioxidant play a crucial role in the prevention and treatment of diseases associated with oxidative stress. Curcumin (CUR), as a natural antioxidant, exhibits numerous therapeutic properties, including antioxidant, anti-inflammatory, antibacterial, and antitumor activities. However, its limited bioavailability and poor water solubility hinder its application as an effective antioxidant.
View Article and Find Full Text PDFHeliyon
August 2024
Department of Mathematics & Physics, North South University (NSU), Dhaka, Bangladesh.
This article investigates the convective thermal and solutal exchange from the active walls of a trapezium chamber which is filled with multi-walled carbon nanotubes (MWCNT)-silicon dioxide (SiO)-ethylene glycol-water hybrid nano-coolant. The hybrid nano-coolant exhibits non-Newtonian shear-thinning rheology and is modeled by the power-law viscosity as per an exploratory report. The convection is generated by both the thermal and solutal buoyancy forces in the presence of a magnetic field.
View Article and Find Full Text PDFSmall Methods
December 2024
Łukasiewicz Research Network - Institute of Microelectronics and Photonics, Aleja Lotników 32/46, 02-668, Warsaw, Poland.
A new class of optical fibers with cores composed of various glass nanorods requires a method to determine the internal structure. In particular, the identification of various ion distributions at the fiber cross-section with nanometer accuracy is required. For this purpose, the classical depth profiling mode of the secondary ion mass spectrometry technique is applied.
View Article and Find Full Text PDFJ Coll Physicians Surg Pak
December 2024
Department of Hepatobiliary Surgery, Wenzhou Central Hospital, The Dingli Clinical Institute of Wenzhou Medical University, Wenzhou, Zhejiang, China.
Understanding the biokinetics of nanoparticles will support the identification of target organs for toxicological endpoints. We investigated the biokinetics of poorly soluble nanomaterials carbon black, multi-walled carbon nanotubes (MWCNT), cerium oxide (CeO), titanium dioxide (TiO), crystalline silica (SiO) in inhalation studies in rodents (the soluble amorphous silica was also included). By reviewing research papers on the inhalation of these substances, we collected physico-chemical data and elemental distribution to organs, urine, and feces.
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