AI Article Synopsis
- Researchers identified a precursor protein that produces the neuropeptide FMRFamide by analyzing its genomic sequence and several cDNA clones.
- The protein comprises 597 amino acids, featuring 28 copies of the tetrapeptide FMRFamide along with other related sequences that resemble mammalian brain peptides.
- The findings imply that genes like pro-opiomelanocortin, pre-pro-enkephalin, and cortico-releasing factor originated from a shared ancestral gene.
Article Abstract
We have characterized a precursor protein which gives rise to the neuropeptide Phe-Met-Arg-Phe-amide (FMRFamide) by determining the nucleotide sequence of a genomic and five cDNA clones. The 597-amino-acid protein contains 28 copies of the tetrapeptide FMRFamide, a single Phe-Leu-Arg-Phe-amide (FLRFamide), and other sequences flanked by paired basic residues, some of which have homologies to mammalian brain peptides. The data presented suggest the genes encoding pro-opiomelanocortin, pre-pro-enkephalin, and the hypothalamic releasing factor, cortico-releasing factor (CRF), arose from a common ancestral gene.
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| http://dx.doi.org/10.1089/dna.1.1986.5.453 | DOI Listing |
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