AI Article Synopsis
- Systemic lupus erythematosus (SLE) is an autoimmune inflammatory disorder linked to immune system dysfunction, particularly involving Th1 cells and associated factors.
- The review focuses on the expression and involvement of the Th1 cell family in SLE, analyzing data from patients and animal studies.
- Key findings include the role of T-bet-related age-associated B cells and the potential of low-dose IL-2 treatment in understanding and possibly targeting lupus pathogenesis.
Article Abstract
Systemic lupus erythematosus (SLE) is an inflammatory disorder related to immunity dysfunction. The Th1 cell family including Th1 cells, transcription factor T-bet, and related cytokines IFNγ, TNFα, IL-2, IL-18, TGF-β, and IL-12 have been widely discussed in autoimmunity, such as SLE. In this review, we will comprehensively discuss the expression profile of the Th1 cell family in both SLE patients and animal models and clarify how the family members are involved in lupus development. Interestingly, T-bet-related age-associated B cells (ABCs) and low-dose IL-2 treatment in lupus were emergently discussed as well. Collection of the evidence will better understand the roles of the Th1 cell family in lupus pathogenesis, especially targeting IL-2 in lupus.
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| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC10757975 | PMC |
| http://dx.doi.org/10.3389/fimmu.2023.1305590 | DOI Listing |
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