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Expression and prognosis analysis of integrin subunit α3 (ITGA3) in papillary thyroid cancer. | LitMetric

AI Article Synopsis

  • Integrin subunit α3 (ITGA3) is a protein that interacts with other proteins outside cells, but its role in papillary thyroid cancer has been under-explored.
  • Analysis showed that ITGA3 levels were significantly higher in papillary thyroid cancer patients compared to normal individuals and it was found to be a strong predictor of recurrence-free survival.
  • Further studies indicated that ITGA3 is associated with genetic changes, links to specific regulatory pathways, and may be targeted by certain microRNAs, suggesting its potential as a biomarker for papillary thyroid cancer progression.

Article Abstract

Integrin subunit α3 (ITGA3) is a member of the integrin family and interacts with extracellular matrix proteins. However, there have been few reports regarding the role of ITGA3 in papillary thyroid cancer. The expression levels of ITGA3 were firstly analyzed by bioinformatics tools and experiments, followed by evaluating its prognostic significance in papillary thyroid cancer patients using Kaplan-Meier, receiver operating characteristic, and Cox regression analyses. Then, cBioportal and GSCA databases were applied to evaluate genetic alterations of ITGA3. Functional enrichment analysis was conducted and the upstream miRNAs of ITGA3 were determined. The results showed that the ITGA3 mRNA and protein levels were higher in the papillary thyroid cancer group than those in the normal group (all P < 0.05). Moreover, ITGA3 performed well in distinguishing the recurrence-free survival (RFS) status and served as an independent prognostic factor of papillary thyroid cancer patients (P < 0.01). Besides, significant relations between ITGA3 and genetic alterations were observed (FDR <0.01). Functional enrichment analysis indicated ECM-receptor interaction and cell adhesion molecules were the shared regulatory pathways. Moreover, ITGA3 might be the target gene of hsa-miR-3129, hsa-miR-181d, hsa-miR-181b, hsa-miR-199a, and hsa-miR-199b. Of note, the ITGA3 mRNA level was reduced after has-miR-199b-3p/5p was overexpressed. In conclusion, ITGA3 could be a reliable biomarker and have potential value in predicting the RFS status of papillary thyroid cancer patients.

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Source
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC10756987PMC
http://dx.doi.org/10.1016/j.heliyon.2023.e23163DOI Listing

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