AI Article Synopsis
- The study investigates whether flexible sigmoidoscopy (FS) impacts the incidence and mortality rates of colorectal cancer (CRC) through a meta-analysis and systematic review.
- FS is associated with a significant reduction in CRC incidence (26%) and mortality (30%), based on data from 702,275 individuals across six randomized controlled trials and one cohort study.
- The researchers advocate for further large-scale clinical studies to further validate these findings.
Article Abstract
Background: The question of whether flexible sigmoidoscopy (FS) for colorectal cancer (CRC) affects incidence or mortality remains unclear. In this study, we conducted a meta-analysis and systematic review to explore this issue.
Methods: A systematic search of , , and was performed for cohort studies (CS), case-control studies, and randomized controlled trials (RCTs) of people who underwent FS and reported mortality or incidence of CRC until 11 December 2022. Relative risk (RR) was applied as an estimate of the effect of interest. To combine the RRs and 95% confidence intervals, a random-effects model was used. The quality of the included studies and evidence was assessed by the Newcastle-Ottawa quality assessment scale, the Jadad scale, and the "Grading of Recommendations Assessment, Development and Evaluation System."
Results: There were a total of six RCTs and one CS, comprising 702,275 individuals. FS was found to be associated with a 26% RR reduction in CRC incidence (RR, 0.74; 95% CI, 0.66-0.84) and a 30% RR reduction in CRC mortality (RR, 0.70; 95% CI, 0.58-0.85). In the incidence subgroup analysis, FS significantly reduced the incidence of CRC compared with non-screening, usual care, and fecal immunochemical testing. Significance was also shown in men, women, distal site, stages III-IV, ages 55-59, and age over 60. In terms of the mortality subgroup analysis, the results were roughly the same as those of incidence.
Conclusion: According to this study, FS might reduce the incidence and mortality of CRC. To confirm this finding, further prospective clinical studies should be conducted based on a larger-scale population.
Systematic Review Registration: https://www.crd.york.ac.uk/prospero/, identifier CRD42023388925.
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| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC10757863 | PMC |
| http://dx.doi.org/10.3389/fonc.2023.1288086 | DOI Listing |
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