Objectives: To determine if vancomycin-resistant (VREfm) carriers carry the same VREfm clone after a minimum follow-up of 365 days. For those carrying the same clone, we investigated the genomic evolution per year per genome.
Methods: We used WGS results to assign VREfm clones to each isolate and determine clone shifts. Finally, we calculated distance in core-genome MLST alleles, and the number of SNPs between consecutive VREfm isolates from patients carrying the same VREfm clone.
Results: In total, 44.2% of patients carried the same VREfm clone, and the genomic evolution was 1.8 alleles and 2.6 SNPs per genome per year.
Conclusions: In our population of long-term carriers, we calculated a molecular clock of 2.6 SNPs.
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|---|---|
| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC10753913 | PMC |
| http://dx.doi.org/10.1093/jacamr/dlad153 | DOI Listing |
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