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Radiochemistry: A Hot Field with Opportunities for Cool Chemistry. | LitMetric

Radiochemistry: A Hot Field with Opportunities for Cool Chemistry.

ACS Cent Sci

Department of Chemistry, University of Wisconsin, 1101 University Avenue, Madison, Wisconsin 53706, United States.

Published: December 2023

AI Article Synopsis

Article Abstract

Recent Food and Drug Administration (FDA) approval of diagnostic and therapeutic radiopharmaceuticals and concurrent miniaturization of particle accelerators leading to improved access has fueled interest in the development of chemical transformations suitable for short-lived radioactive isotopes on the tracer scale. This recent renaissance of radiochemistry is paired with new opportunities to study fundamental chemical behavior and reactivity of elements to improve their production, separation, and incorporation into bioactive molecules to generate new radiopharmaceuticals. This outlook outlines pertinent challenges in the field of radiochemistry and indicates areas of opportunity for chemical discovery and development, including those of clinically established (C-11, F-18) and experimental radionuclides in preclinical development across the periodic table.

Download full-text PDF

Source
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC10755734PMC
http://dx.doi.org/10.1021/acscentsci.3c01050DOI Listing

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