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Potentiating-antibiotic activity and absorption, distribution, metabolism, excretion and toxicity properties (ADMET) analysis of synthetic thiadiazines against multi-drug resistant (MDR) strains.
Fundam Clin Pharmacol
February 2024
Laboratory of Microbiology and Molecular Biology, LMBM, Universidade Regional do Cariri, Crato, Brazil.
Background: Thiadiazines are heterocyclic compounds that contain two nitrogen atoms and one sulfur atom in their structure. These synthetic molecules have several relevant pharmacological activities, such as antifungal, antibacterial, and antiparasitic.
Objectives: The present study aimed to evaluate the possible in vitro and in silico interactions of compounds derived from thiadiazines.
Cirrhosis and Portal Hypertension: How Do We Deal with Ascites and Its Consequences.
Med Clin North Am
May 2023
Unit of Internal Medicine and Hepatology, Department of Medicine, University of Padova, Padova, Italy. Electronic address:
Ascites is the most common complication of cirrhosis, with 5-year mortality reaching 30%. Complications of ascites (ie, spontaneous bacterial peritonitis, hepatorenal syndrome, recurrent/refractory ascites, and hepatic hydrothorax) further worsen survival. The development of ascites is driven by portal hypertension, systemic inflammation, and splanchnic arterial vasodilation.
View Article and Find Full Text PDFNew Cu Complexes with N-Sulfonamide Ligands: Potential Antitumor, Antibacterial, and Antioxidant Agents.
Molecules
May 2022
National Institute for Research and Development of Isotopic and Molecular Technologies, 400293 Cluj-Napoca, Romania.
Article Synopsis
- - The research focuses on the synthesis of two new non-toxic copper complexes (C1 and C2) with potential biological activity, characterized by their five-coordinated structure and unique ligands.
- - Both complexes were found to cleave DNA, demonstrate SOD mimetic activity, and exhibit cytotoxic effects on tumor (HeLa, WM35) and normal (HFL1) cell lines, with C2 showing greater biological activity.
- - The C2 complex showed no in vivo toxicity in mice during hepatic, renal, and hematological studies, and displayed antibacterial activity against various bacteria, outperforming standard antibiotics like Amoxicillin and Norfloxacin.
Rifaximin Vs. Norfloxacin for Spontaneous Bacterial Peritonitis Prophylaxis: A Randomized Controlled Trial.
J Clin Exp Hepatol
August 2021
Department of Hepatology, Post Graduate Institute of Medical Education and Research, Chandigarh, 160012, India.
Background: Spontaneous bacterial peritonitis (SBP) heralds increased mortality in cirrhosis, mandating strategies for prophylaxis. Norfloxacin has been the recommended choice for SBP prevention. However, its use has raised concerns about antibiotic resistance.
View Article and Find Full Text PDFEffect of poorly absorbable antibiotics on hepatic venous pressure gradient in cirrhosis: A systematic review and meta-analysis.
Dig Liver Dis
September 2020
UVCM, Inselspital, Bern University Hospital, Department of Biomedical Research, University of Bern, Switzerland. Electronic address:
Background: The effects of poorly/non-absorbable antibiotics on hepatic venous pressure gradient (HVPG) are debated.
Aim: To analyze the effects of rifaximin or norfloxacin on HVPG and on markers of bacterial translocation and proinflammatory cytokines.
Methods: We performed a systematic search of randomized clinical trials (RCTs) involving patients with cirrhosis and portal hypertension, assessing the effect of rifaximin or norfloxacin vs control on HVPG.
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