AI Article Synopsis

  • - Bladder cancer (BC) patients can experience shrinkage due to radiation-induced fibrosis, and specific microRNAs (miRNAs) are linked to this injury and overall survival.
  • - In a study of three Japanese BC patients, certain miRNAs (such as hsa-miR-130a and hsa-miR-200c) were highly expressed in those with fibrotic bladder shrinkage compared to patients with intact bladder function.
  • - Analysis of 409 BC patients revealed that high expression of specific miRNAs correlated with significantly longer median survival, indicating a potential role for these miRNAs in predicting patient outcomes and targeting profibrotic cytokines.

Article Abstract

Introduction: Bladder cancer (BC) is sensitive to radiation treatment and a subset of patients experience radiation-induced injuries including shrinkage of bladder due to bladder fibrosis.

Methods: This study is a retrospective cohort study. Three Japanese BC patients were randomly selected. Using a microRNA (miRNA) array, comparing their samples with or without radiation-induced injuries, we have checked the clustering of miRNA expression.

Results: Hsa-miR-130a, hsa-miR-200c, hsa-miR-141, and hsa-miR-96 were found to be highly expressed (>50 times) in patients with fibrotic bladder shrinkage (FBS) compared to those with intact bladder (IB) function. In patients with FBS, hsa-miR-6835, hsa-miR-4675, hsa-miR-371a, and hsa-miR-6885 were detected to have lesser than half expression to IB patients. We have analyzed the significance of these genes in relation to overall survival of 409 BC patients retrieved from the Cancer Genome Atlas data set. All available cutoff values between the lower and upper quartiles of expression are used for the selected genes, and false discovery rate using the Benjamini-Hochberg method is computed to correct for multiple hypothesis testing. We have run combined survival analysis of the mean expression of these four miRNAs highly expressed in FBS patients. 175 patients with high expression had a longer median survival of 98.47 months than 23.73 months in 233 patients with low expression (hazard ratio [HR]: 0.53; 0.39-0.72, log-rank p value: 7.3e-0.5). Combination analysis of all 8 genes including hsa-miR-6835, hsa-miR-4675, hsa-miR-371a, and hsa-miR-6885 showed the same HR for OS. Target scanning for these miRNAs matched specific cytokines known as an early biomarker to develop radiation-induced fibrosis.

Conclusions: BC patients with fibrotic radiation injury have specific miRNA expression profile targeting profibrotic cytokines and these miRNAs possibly render to favorable survival.

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Source
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC11216355PMC
http://dx.doi.org/10.1159/000535993DOI Listing

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