Significant association between circumvallate placenta, placental abruption and acute chorioamnionitis in preterm birth: A 23-year retrospective cohort study.

Placenta

Department of Pathology, Leiden University Medical Centre, 2333 ZA, Leiden, the Netherlands; Department of Pathology, Erasmus Medical Centre, Rotterdam, the Netherlands. Electronic address:

Published: February 2024

Aim: circumvallate placenta, placental abruption and acute chorioamnionitis separately are associated with unfavourable clinical outcomes. We aimed to determine the prevalence and define whether an association exists between the three abnormalities.

Methods: 16,042 placenta pathology reports between 1997 and 2020 from a tertiary care centre in the Netherlands were retrospectively analysed. For the statistical analysis, the chi-square test and bootstrapping were used to evaluate an association.

Results: In our cohort the prevalence of circumvallate placenta is 2.2 %, placental abruption cases 4.0 % and acute chorioamnionitis 20.6 %. We observed a statistically significant association between all three placental abnormalities: circumvallate placenta, placental abruption and acute chorioamnionitis. In addition, there was also an association between circumvallate placenta and acute chorioamnionitis.

Conclusion: Our results show that combined presence of circumvallate placenta, placental abruption and acute chorioamnionitis are associated in preterm birth (p = 0.001). A remarkable finding is that the combination of all three abnormalities (circumvallate placenta, placental abruption and acute chorioamnionitis) was not observed in term pregnancies >37 weeks.

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.placenta.2023.12.018DOI Listing

Publication Analysis

Top Keywords

circumvallate placenta
28
placental abruption
24
acute chorioamnionitis
24
placenta placental
20
abruption acute
20
association circumvallate
8
placenta
8
preterm birth
8
abnormalities circumvallate
8
placental
7

Similar Publications

Want AI Summaries of new PubMed Abstracts delivered to your In-box?

Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!