Unlocking the biosynthesis of psychedelic-inspired indolethylamines.

Trends Biochem Sci

Department of Chemical, Paper, and Biomedical Engineering, Miami University, Oxford, OH 45056, USA. Electronic address:

Published: March 2024

A recent report by Chen et al. describes the discovery of RmNMT, a highly active and promiscuous tryptamine N-methyltransferase from the cane toad, Rhinella marina. N,N-dimethyltryptamine derivatives produced by this enzyme were then evaluated for their potential to serve as next-generation treatments for mental health disorders.

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http://dx.doi.org/10.1016/j.tibs.2023.12.009DOI Listing

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