AI Article Synopsis
- Sepsis is a serious condition caused by an abnormal immune response to infection, and the study focuses on how genetic differences in the vitamin D receptor (VDR) gene, specifically the FokI polymorphism, may influence outcomes in sepsis patients.
- The study analyzed 192 patients (96 with sepsis and 96 without) in the ICU and found that in-hospital mortality was significantly higher in the sepsis group (27.1%) compared to the non-sepsis group (8.33%).
- Results indicated that while there was no significant difference in VDR genotype frequencies between survivors and non-survivors in the sepsis group, those with the homozygous C allele had lower mortality rates, suggesting a potential
Article Abstract
Background: Sepsis is life-threatening organ dysfunction as a result of the host's dysregulated immune response to infection. The vitamin D receptor (VDR) gene FokI polymorphism influences immune cell behavior. In the present study, we aimed to investigate the association between VDR FokI polymorphism and mortality in sepsis and non-sepsis patients in the intensive care unit (ICU).
Methods And Results: This is a prospective observational study involving 96 sepsis and 96 non-sepsis patients admitted to the Ege University ICU. VDR FokI polymorphisms were investigated, as well as the relationship between the identified polymorphisms and mortality. In-hospital mortality was 27.1% in the sepsis group and 8.33% in the non-sepsis group (p = 0.001). The frequencies of VDR FokI TT, TC, and CC genotypes were 8 (8.33%), 48 (50.0%), and 40 (41.7%) in the sepsis group, and 11 (11.5%), 42 (43.8%), and 43 (44.8%) in the non-sepsis group, respectively (p = 0.612). In the sepsis group, the frequencies of Fokl TT, TC, and CC genotypes did not differ significantly between survivors and non-survivors. However, homozygous C allele carriers had lower overall mortality (p = 0.047).
Conclusion: The VDR FokI polymorphism, particularly the CC genotype, appears to be associated with lower mortality in ICU patients.
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| http://dx.doi.org/10.1007/s11033-023-08971-8 | DOI Listing |
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