AI Article Synopsis
- * Lipid metabolism alterations allow cancer cells to enhance their growth and energy needs by increasing lipid synthesis and modifying fatty acid oxidation.
- * Changes in amino acid metabolism also play a crucial role, as PCa cells require specific amino acids for their survival and proliferation, highlighting the need for in-depth metabolic studies to improve diagnosis and treatment.
Article Abstract
Prostate cancer (PCa) is one of the most common malignancies in males worldwide, and its development and progression involve the regulation of multiple metabolic pathways. Alterations in lipid metabolism affect the proliferation and metastatic capabilities of PCa cells. Cancer cells increase lipid synthesis and regulate fatty acid oxidation to meet their growth and energy demands. Similarly, changes occur in amino acid metabolism in PCa. Cancer cells exhibit an increased demand for specific amino acids, and they regulate amino acid transport and metabolic pathways to fulfill their proliferation and survival requirements. These changes are closely associated with disease progression and treatment response in PCa cells. Therefore, a comprehensive investigation of the metabolic characteristics of PCa is expected to offer novel insights and approaches for the early diagnosis and treatment of this disease.
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Source |
|---|---|
| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC10919422 | PMC |
| http://dx.doi.org/10.4103/aja202363 | DOI Listing |
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