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Effect of sitagliptin therapy on IL-29 and its associated signaling molecules in patients with type 2 diabetes mellitus.
Hum Immunol
July 2024
Department of Immunology, School of Medicine, Hamadan University of Medical Sciences, Hamadan, Iran. Electronic address:
Objective: The potential immunoregulatory capacity of sitagliptin on interleukin-29 (IL-29) and genes involved in its intracellular pathway were explored in type 2 diabetes mellitus (T2D).
Materials And Methods: T2D patients treated with six months of sitagliptin (Sita), patients not treated with sitagliptin (Sita), and healthy controls (HCs) were included. IL-29 levels in the supernatant of stimulated mononuclear immune cells was determined with ELISA.
IFNL1 rs30461 polymorphism as a risk factor for COVID-19 severity: A cross-sectional study.
Cytokine
April 2024
Department of Medical Biochemistry and Molecular Biology, Faculty of Medicine, Mansoura University, Mansoura, Egypt.
Introduction: The molecular basis of the progression of some COVID-19 patients to worse outcomes is not entirely known. Interferons-lambda-1/interleukin-29 (IFN-λ1/IL-29) is a member of the type III IFNs with a strong antiviral activity. Given the scant data on the potential role of IFN-λ1/IL-29 in COVID-19, we investigated the association of IFN-λ1/IL-29 serum level and the IFNL1 single-nucleotide polymorphism (SNP) (rs30461) with severe course of COVID-19.
View Article and Find Full Text PDFInterleukin-29 level in psoriasis before and after narrow-band ultraviolet B and its relationship with metabolic syndrome.
Arch Dermatol Res
December 2023
Dermatology Department, Faculty of Medicine, Cairo University, Kasr AlAiny Street, Cario, 11562, Egypt.
Enhanced soluble expression of active recombinant human interleukin-29 using champion pET SUMO system.
Biotechnol Lett
August 2023
Centre of Excellence in Molecular Biology, University of the Punjab, Lahore, Pakistan.
Current research focuses on the soluble and high-level expression of biologically active recombinant human IL-29 protein in Escherichia coli. The codon-optimized IL-29 gene was cloned into the Champion™ pET SUMO expression system downstream of the SUMO tag under the influence of the T7 lac promoter. The expression of SUMO-fused IL-29 protein was compared in E.
View Article and Find Full Text PDFEnhanced production of interleukin-29 and related genes are associated with T helper 1 cell parameters in patients with type 2 diabetes mellitus.
Hum Immunol
March 2023
Department of Immunology, School of Medicine, Hamadan University of Medical Sciences, Hamadan, Iran. Electronic address:
Objective: The production of interleukin (IL)-29 andthe genes related to IL-29 signaling pathway (STAT1, NF-κB, and NFATc1), and T helper (Th) 1 cells (T-bet, IFN-γ, TNF-α, and IL-2) were evaluated in type 2 diabetes mellitus (T2DM). Correlations between IL-29 and diabetes parameters, and between gene expression in IL-29 pathway and Th1 cells were also examined.
Materials And Methods: 41 newly diagnosed patients with T2DM and 41 healthy controls were recruited.
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