AI Article Synopsis
- The study examined whether microvessel density (MVD) in colorectal cancer tissues could predict vascular invasion (VI) in patients.
- Analysis included surgical specimens from 73 colorectal adenocarcinoma patients, excluding those who received preoperative treatments.
- Results indicated that while MVD was slightly higher in specimens with VI, it wasn't statistically significant; however, a higher MVD (above 60 vessels per field) was linked to a significantly increased risk of VI, establishing MVD as a potential prognostic marker.
Article Abstract
Objective: This study aimed to determine whether microvessel density (MVD) in the tumor tissues could be a potential predictive marker for vascular invasion (VI).
Methods: Surgical specimens of 73 patients with colorectal adenocarcinoma in Phramongkutklao Hospital were analyzed. Tissues of patients receiving preoperative radiation or prior anti-angiogenic therapy were excluded. Tumor MVD was determined using the average number of counted CD34-stained endothelial cells from two selected fields at 200x magnification in each slide. The presence of VI was defined by tumor involvement of endothelial cell-lined spaces. The optimal cut-off value of MVD to predict VI was examined using receiver operating characteristic analysis to assess the area under the curve and accuracy.
Result: VI was detected in 17 of 73 specimens (23.3%). Colorectal cancer (CRC) specimens were classified according to MVD as low (61 specimens, 83.6%) and high density (12 specimens, 16.4%). Average MVD was slightly higher in specimens with VI (81.3±9.3) than those without VI (76.3±7.6), but without statistical significance (p = 0.736). The MVD's cut-off value of 60 vessels/200x field provided 88% sensitivity, 40% specificity, and 57.5% accuracy, with the area under the ROC curve of 0.5788. Patients with CRC having MVD of > 60 vessels/200x field were at significantly higher risk of VI than those with CRC having MVD of <60 vessels/200x field (P=0.009, Fisher's exact test). Univariate analysis revealed that MVD, nodal involvement and AJCC tumor stage were associated with the presence of VI (p <0.05). Further multivariate analysis of these three potential variables demonstrated MVD (OR, 11.994; 95% CI, 2.197 to 65.483; p <0.01) and nodal involvement (OR, 10.767; 95% CI, 1.973 to 58.748; p <0.05) as independent prognostic factors associated with VI.
Conclusion: Based on our study, MVD immunostaining was an angiogenic marker that potentially be a predictive marker for VI.
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| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC10909077 | PMC |
| http://dx.doi.org/10.31557/APJCP.2023.24.12.4097 | DOI Listing |
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