Inflammatory bowel diseases (Crohn's disease, ulcerative colitis) are chronic immune-mediated diseases of the gastrointestinal tract that are associated with many extraintestinal manifestations (EIMs). EIMs can affect nearly any organ system and are associated with impaired quality of life. This issue of The Clinical and Translational Gastroenterology includes a cross-sectional study of EIMs within the GETAID cohort, one of the largest to date reporting on the prevalence, risk factors, and predictors of remission for EIMs. We discuss how these results fit with existing literature and how clinicians may incorporate these insights into practice.
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http://dx.doi.org/10.14309/ctg.0000000000000618 | DOI Listing |
Nutrients
December 2024
Department of Gastroenterology and Hepatology, Pomeranian Medical University in Szczecin, 70-204 Szczecin, Poland.
Background/objectives: Crohn's disease is known for being associated with an abnormal composition of the bacterial flora, dysbiosis and intestinal function disorders. Metabolites produced by gut microbiota play a pivotal role in the pathogenesis of CD, and the presence of unspecific extraintestinal manifestations.
Methods: The aim of this study was a determination of the level of bacterial metabolites in blood plasma in patients with Crohn's disease.
Clin Nucl Med
December 2024
From the Department of Neurology, Yueyang Hospital of Integrated Traditional Chinese and Western Medicine, Shanghai University of Traditional Chinese Medicine.
Gardner syndrome is characterized by multiple intestinal polyps and extraintestinal lesions. We describe FDG PET/CT findings of the extraintestinal lesions in a patient with Gardner syndrome. FDG PET/CT showed 2 hypermetabolic desmoid tumors in the abdominal wall, sclerotic areas with multifocal activity in the maxilla and mandible, multiple osteomas in the bilateral parietal, left frontal, sphenoid and ethmoid bones, an impacted tooth in the right maxilla, and bone islands in the T2 and T5 vertebral bodies.
View Article and Find Full Text PDFSci Rep
January 2025
Department of Colorectal Surgery, Jiangsu Province Hospital of Chinese Medicine, The Affiliated Hospital of Nanjing University of Chinese Medicine, Nanjing, 210029, PR China.
Inflammatory bowel disease (IBD) is a multisystem condition that could affect the cutaneous systems, namely cutaneous extraintestinal manifestations (EIMs). It has been suggested that IBD is associated with erythema nodosum (EN), malignant melanoma (MM) and non-melanoma skin cancer (NMSC). However, the potential causal relationship between IBD and the mentioned above cutaneous EIMs is still unclear.
View Article and Find Full Text PDFTherap Adv Gastroenterol
January 2025
Department of Gastroenterology, Peking University First Hospital, No. 8 Xishiku Street, Xicheng District, Beijing 100034, China.
Background: Inflammatory bowel disease (IBD), including ulcerative colitis (UC) and Crohn's disease (CD), can affect the hepatobiliary system and pancreas, substantially impacting the life quality of patients.
Objectives: To evaluate the quality of evidence and comprehensively assess the validity of associations of IBD with hepatobiliary and pancreatic diseases.
Design: We performed an umbrella review of existing meta-analyses in accordance with the Preferred Reporting Items for Systematic Review and Meta-Analyses (PRISMA) recommendations.
Inn Med (Heidelb)
January 2025
Dr. von Haunersches Kinderspital, Kinderklinik und Kinderpoliklinik, Ludwig-Maximilians-Universität München, Lindwurmstr. 4, 80337, München, Deutschland.
Pediatric-onset inflammatory bowel disease (PIBD) is increasingly recognized in Germany. Patients with PIBD often present with more extensive and active disease. Clinical suspicion of IBD requires early initiation of the diagnostic work-up (e.
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