AI Article Synopsis
- Vulvar lichen sclerosus (LS) is a chronic inflammatory condition that can lead to serious complications like differentiated vulvar intraepithelial neoplasia (dVIN) and vulvar squamous cell carcinoma (VSCC), making its management critical especially post-surgery for VSCC.
- A survey of 44 gynecologic oncologists in the Netherlands revealed that topical corticosteroids (TCS) are prescribed more frequently for LS patients without a history of VSCC compared to those following surgery for VSCC (86% vs. 52%).
- Both patient groups are primarily treated with ultra-potent TCS for symptom relief and to prevent progression to serious conditions, though guidelines on post-surgery LS management remain unclear.
Article Abstract
Background: Vulvar lichen sclerosus (LS) is a chronic inflammatory dermatosis which can progress to precursor lesion differentiated vulvar intraepithelial neoplasia (dVIN) and vulvar squamous cell carcinoma (VSCC). The risk of developing recurrent vulvar cancer following LS-associated VSCC is high. Evidence suggests that treatment of LS with topical corticosteroids (TCS) can prevent progression to dVIN, VSCC and recurrences. However, current guidelines do not give any recommendation on the management of LS following surgery for VSCC. The aim of this study was to conduct a survey among all registered gynaecologic oncologists (GOs) in the Netherlands to evaluate the current management of LS patients without a history of VSCC (LS) and patients with LS following surgery for VSCC (LS).
Methods: An online survey was distributed to all registered GOs in the Netherlands. Primary outcome measures were the frequency, type and duration of TCS treatment prescribed for LS and LS patients, separately. As a secondary outcome measure, reasons for treating or not treating patients with LS and LS with TCS were analysed.
Results: Forty-four GOs completed the survey, resulting in a response rate of 75%. TCS were prescribed more often to patients with LS as compared to patients with LS (86% 52%, respectively, < 0.001). If treatment was initiated, ultra-potent (class IV) TCS were most commonly prescribed for an indefinite period of time for both patient groups. The most reported reason for treating patients in both groups with TCS was symptoms, followed by clinical aspects of the lesion and prevention of progression to dVIN and VSCC.
Conclusion: The majority of GOs who participated in our study endorse the utilisation of long-term ultra-potent TCS therapy in both patients with LS and LS. Nevertheless, Dutch GOs are currently prescribing TCS more frequently to patients with LS than to patients with LS.
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| http://dx.doi.org/10.1080/01443615.2023.2294330 | DOI Listing |
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