Ameloblastoma is a benign yet locally aggressive tumor of the jaw bones and is most commonly found in the lower mandibular region. Histologically, it shows benign characteristics. However, ameloblastoma can turn malignant to show a more aggressive clinical course. Carcinoma ex ameloblastoma is an extremely rare malignancy arising from a pre-existing long-standing ameloblastoma or a recurrence of an ameloblastoma. According to the literature search, six to seven cases have so far been documented, and the majority of the lesions had a propensity to metastasize. Here, we present a case of carcinoma ex ameloblastoma implicating a 19-year-old male patient manifesting in the mandible, which arises from pre-existing ameloblastoma.
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http://dx.doi.org/10.7759/cureus.49536 | DOI Listing |
J Clin Exp Dent
December 2024
Department of Oral Surgery and Oral Medicine, Faculty of Dentistry, Srinakharinwirot University.
Background: N6-methyladenosine (m6A), the most abundant internal RNA modification in mammals, plays a critical role in many forms of cancer. Methyltransferase-like 3 (METTL3) serves as the main catalytic subunit of the m6A writer and plays a role in the progression of head and neck squamous cell carcinoma. To date, the role of METTL3 in odontogenic lesions has never been investigated.
View Article and Find Full Text PDFJ Stomatol Oral Maxillofac Surg
November 2024
Sorbonne Université, Paris, France; Department of Maxillo-Facial Surgery, Hôpital Pitié-Salpêtrière, Assistance Publique des Hôpitaux de Paris, Paris, France; Sorbonne université, INSERM UMRS 938, Centre de Recherche de Saint Antoine, Team Cancer Biology and Therapeutics, France.
Introduction: The prognosis of metastatic ameloblastoma (METAM), now defined as a benign tumor, and malignant odontogenic tumors (MOT) is poorly studied in the literature. The aim of this study was to determine the prognosis and factors influencing the survival of these patients.
Material And Methods: Using the SEER database, we retrieved clinical data of patients with malignant tumors of dental origin between 1975 and 2020.
Rofo
November 2024
Department of Oral and Maxillofacial Surgery, University Hospital Augsburg, Augsburg, Germany.
Primary bone tumours of the jaw are rare tumoral entities and do substantially differ from other bone tumours of the human body with respect of their frequently encountered unusual radiological appearances. The reason for that may be confined to the co-existence of two closely neighbored but different anatomical structures (i.e.
View Article and Find Full Text PDFRofo
November 2024
Department of Oral and Maxillofacial Surgery, University Hospital Augsburg, Augsburg, Germany.
Primary bone tumours of the jaw are rare tumoral entities and do substantially differ from other bone tumours of the human body with respect of their frequently encountered unusual radiological appearances. The reason for that may be confined to the co-existence of two closely neighbored but different anatomical structures (i.e.
View Article and Find Full Text PDFOral Radiol
November 2024
, Fukuoka, Japan.
Primary intraosseous carcinoma not otherwise specified (PIOC NOS) is a rare tumor assumed to arise from the epithelium, such as odontogenic cysts or benign tumors. Its clinical and imaging diagnoses are often challenging, especially in the early stages, as it mimics jaw cysts and benign tumors, and no specific findings have been identified. This report presents the case of a 66-year-old male patient with mandibular PIOC, highlighting the imaging findings over time.
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