AI Article Synopsis
- The study examines the frequencies of the top 10 Alzheimer's disease risk genes in Mexican Americans (MAs) and non-Hispanic Whites (NHWs) from a community-based cohort.
- Genetic testing revealed significant differences in allele frequencies for 9 out of 11 genetic variants between the two groups, highlighting possible ethnicity-specific genetic risks for Alzheimer's disease.
- These findings indicate a need for further research to explore and understand the genetic differences related to Alzheimer's risk across different ethnic populations.
Article Abstract
: Here we evaluate frequencies of the top 10 Alzheimer's disease (AD) risk alleles for late-onset AD in Mexican American (MA) and non-Hispanic White (NHW) American participants enrolled in the Health and Aging Brain Study-Health Disparities Study cohort. : Using DNA extracted from this community-based diverse population, we calculated the genotype frequencies in each population to determine whether a significant difference is detected between the different ethnicities. DNA genotyping was performed per manufacturers' protocols. : Allele and genotype frequencies for 9 of the 11 single nucleotide polymorphisms (two apolipoprotein E variants, and ) differed significantly between MAs and NHWs. : The significant differences in frequencies of top AD risk alleles observed here across MAs and NHWs suggest that ethnicity-specific genetic risks for AD exist. Given our results, we are advancing additional projects to further elucidate ethnicity-specific differences in AD.
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| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC10752755 | PMC |
| http://dx.doi.org/10.1002/dad2.12518 | DOI Listing |
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