Introduction: Age-related cognitive decline has been linked to distinct patterns of cellular dysfunction in the prelimbic cortex (PL) and the CA3 subregion of the hippocampus. Because higher cognitive functions require both structures, selectively targeting a neurobiological change in one region, at the expense of the other, is not likely to restore normal behavior in older animals. One change with age that both the PL and CA3 share, however, is a reduced ability to utilize glucose, which can produce aberrant neural activity patterns.
Methods: The current study used a ketogenic diet (KD) intervention, which reduces the brain's reliance on glucose, and has been shown to improve cognition, as a metabolic treatment for restoring neural ensemble dynamics in aged rats. Expression of the immediate-early genes and 1a were used to quantify the neural ensembles that were active in the home cage prior to behavior, during a working memory/biconditional association task, and a continuous spatial alternation task.
Results: Aged rats on the control diet had increased activity in CA3 and less ensemble overlap in PL between different task conditions than did the young animals. In the PL, the KD was associated with increased activation of neurons in the superficial cortical layers, establishing a clear link between dietary macronutrient content and frontal cortical activity. The KD did not lead to any significant changes in CA3 activity.
Discussion: These observations suggest that the availability of ketone bodies may permit the engagement of compensatory mechanisms in the frontal cortices that produce better cognitive outcomes.
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http://dx.doi.org/10.3389/fnagi.2023.1274624 | DOI Listing |
Open Vet J
November 2024
Department of Animal Nutrition and Feed Science, Faculty of Animal Science, Universitas Gadjah Mada, Yogyakarta, Indonesia.
Background: The lactation period is a crucial period where the nutritional status and the mother's environment influence milk production, impacting organ differentiation, function, and structure in the baby's body.
Aim: The study aimed to determine the impact of providing lactating rats with quail egg supplements enriched with marine macroalgae on their physiological condition (blood cells, lipids, blood glucose, antioxidant activity, and prolactin hormone levels) and the growth of their offspring.
Methods: The study involved 25 lactating Sprague Dawley white rats aged 3 months old and weighing approximately 200 g divided into five treatment groups thus; T0 as the control, T1 with quail eggs enriched with commercial feed, T2 with quail eggs enriched with 3% of marine macroalgae, T3 with quail eggs enriched with 4% of marine macroalgae, and T4 with quail eggs enriched with 5% of marine macroalgae, which received one quail egg for 21 days.
Pol J Vet Sci
June 2024
Department of Anatomy, Medical Faculty, Mardin Artuklu University, Artuklu, 47200, Mardin, Turkey.
In this study, the relationship between plasma ghrelin levels and muscle atrophy was examined in an experimental diabetic rat model. 56 male Wistar albino rats, aged 8-10 weeks, were used in the study. The rats were divided into 8 groupsD1: one-week diabetes, C1: one-week control, D2: three-week diabetes, C2: three-week control, D3: six-week diabetes, C3: six-week control, D4: eight-week diabetes, C4: eight-week control.
View Article and Find Full Text PDFSci Rep
December 2024
Auckland Bioengineering Institute, The University of Auckland, Auckland, New Zealand.
Cardiac sex-difference functional studies have centred on measurements of twitch force and Ca dynamics. The energy expenditures from these two cellular processes: activation (Ca handling) and contraction (cross-bridge cycling), have not been assessed, and compared, between sexes. Whole-heart studies measuring oxygen consumption do not directly measure the energy expenditure of these activation-contraction processes.
View Article and Find Full Text PDFBone
December 2024
First Affiliated Hospital, Guangzhou University of Chinese Medicine, Guangzhou, China. Electronic address:
Induced membrane technique (IMT) is a new method for repairing segmental bone defects. However, the mechanism of its defect repair is not clear. In recent years, several studies have gradually indicated that ferroptosis is closely related to bone remodeling.
View Article and Find Full Text PDFSynapse
January 2025
Department of Neurology, The First Affiliated Hospital of Kunming Medical University, Kunming, Yunnan, China.
Mammalian sterile20-like kinase 1 (MST1), a serine/threonine kinase frequently expressed, has emerged as pivotal modulator of multiple physiological and pathological conditions such as cellular growth, programmed cell death, oxidative stress, neurodegeneration, inflammation, and synaptic plasticity in the central nervous system. Various neurological diseases are associated with the activation of MST1. Epilepsy is a severe neurological disorder characterized by abrupt abnormal electrical activity in the brain and recurring spontaneous seizures.
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