AI Article Synopsis
- Protein arginine methylation is a key modification process in cells that influences important functions like gene expression and cell signaling.
- PRMT2, a member of the protein arginine methyltransferase family, is less studied but plays significant roles in regulating transcription, immune responses, and developmental processes.
- The review covers PRMT2's structure and functions, its links to various diseases, and discusses potential inhibitors for therapeutic use.
Article Abstract
Protein arginine methylation stands as a prevalent post-translational modification process, exerting vital roles in cellular signal transduction, gene expression, and cell cycle regulation. Amidst the protein arginine methyltransferase (PRMT) family, PRMT2 stands as a less explored constituent. Nonetheless, its regulatory roles in transcriptional regulation, post-transcriptional modification, methylation activity regulation, immunoregulation, and developmental regulation have garnered attention. These capabilities enable PRMT2 to exert pivotal regulatory functions in certain malignancies, metabolic disorders, inflammatory diseases, and atherosclerosis. In this review, we highlight the structure and functions of PRMT2, emphasizing its association with diseases. We also discuss PRMT2 inhibitors and explore the potential for therapeutic targeting.
Download full-text PDF |
Source |
|---|---|
| http://dx.doi.org/10.2174/0109298665281395231211060535 | DOI Listing |
Publication Analysis
Top Keywords
Similar Publications
Want AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!