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Optical Methods for the Study of Brain Metabolism In Situ.
Adv Exp Med Biol
October 2024
Department of Physiology & Biophysics, Case Western Reserve University School of Medicine, Cleveland, OH, USA.
From its inception, the International Society of Oxygen Transport to Tissue (ISOTT) included several core members who were intrigued by the possibility of using light to probe the metabolic state of the cerebral cortex. This 50th anniversary review will focus on optical methods (UV, Visible, NIR) used to study brain oxygen metabolism in the intact brain. Chance, Lübbers, and Jöbsis did fundamental work in the 1970s and 1980s.
View Article and Find Full Text PDFSex-specific impacts of prenatal bisphenol A exposure on genes associated with cortical development, social behaviors, and autism in the offspring's prefrontal cortex.
Biol Sex Differ
May 2024
Chulalongkorn Autism Research and Innovation Center of Excellence (Chula ACE), Department of Clinical Chemistry, Faculty of Allied Health Sciences, Chulalongkorn University, 154 Soi Chula 12, Rama 1 Road, Bangkok, Wangmai, Pathumwan, 10330, Thailand.
Background: Recent studies have shown that prenatal BPA exposure altered the transcriptome profiles of autism-related genes in the offspring's hippocampus, disrupting hippocampal neuritogenesis and causing male-specific deficits in learning. However, the sex differences in the effects of prenatal BPA exposure on the developing prefrontal cortex, which is another brain region highly implicated in autism spectrum disorder (ASD), have not been investigated.
Methods: We obtained transcriptome data from RNA sequencing analysis of the prefrontal cortex of male and female rat pups prenatally exposed to BPA or control and reanalyzed.
Cortex 60 anniversary: Reminiscence and comments.
Cortex
January 2024
Edinburgh University, Edinburgh, UK. Electronic address:
Time-travel to "A review and proposal for a model of sensory predictability in auditory language perception".
Cortex
January 2024
Department of Neuropsychology and Psychopharmacology, Maastricht University, Maastricht, Netherlands.
Since its inception 60 years ago, the mission of Cortex has been to foster a better understanding of cognition and the relationship between the nervous system, behavior in general, and mental processes in particular. Almost 15 years ago, we submitted "a review and proposal" along these lines to the journal, in which we sought to integrate two components that are not often discussed together, namely the basal ganglia and syntactic language functions (Kotz et al., 2009).
View Article and Find Full Text PDFEditorial: 90th anniversary of the Sherrington and Adrian Nobel Prize: brain rhythms and oscillations in neural activity modulation, brain function and dysfunction.
Front Cell Neurosci
November 2023
Department of Physiology and Pharmacology, University of Western Ontario, London, ON, Canada.
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