Ophiocordyceps sinensis (OS), known as "soft gold", played an important role in local economic development. OS from different producing areas was difficult to be discriminated by the appearance. Nagqu OS, a distinguished and safeguarded geographical indication product, commands a premium price in market. The real claim of OS geographical origins is urgently required. Here, 81 OS samples were collected from Tibetan Plateau in China to explore markers for tracing origins. OS from Xigazê can be distinguished by dark color of head of caterpillar. Then 57 samples, a fully representative training-sample set, were used to set up OPLS-DA models by nontargeted metabolomics from UPLC-QTOF-MS. Certain markers were successfully identified and validation using 21 blind test samples confirmed that the markers can trace the geographical origin of OS, especially Nagqu samples. It was affirmed that UPLC-QTOF-MS-based untargeted metabolomics coupled with OPLS-DA was a reliable strategy to trace the geographical origins of OS.
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http://dx.doi.org/10.1016/j.foodchem.2023.138247 | DOI Listing |
Mol Biol (Mosk)
December 2024
Peoples' Friendship University of Russia, Moscow, 117198 Russia.
The E6 and E7 proteins of the high risk human papillomaviruses (HR HPVs) play a key role in the oncogenesis associated with papillomavirus infection. Data on the variability of these proteins are limited, and the factors affecting their variability are still poorly understood. We analyzed the variability of the currently known sequences of the HPV type 16 (HPV16) E6 and E7 proteins, taking into account their geographic origin and year of sample collection, as well as the direction of their evolution in the major geographic regions of the world.
View Article and Find Full Text PDFVirologie (Montrouge)
December 2024
The Human papillomaviruses (HPV) have existed in the human population since the archaic hominids. Over the course of human migration and evolution, HPVs have co-evolved with humans on all continents to become today the leading cause of cervical cancer. HPVs are classified by genera, species, genotype, lineage, sub-lineage and variants.
View Article and Find Full Text PDFVirol J
December 2024
Istituto Zooprofilattico Sperimentale della Lombardia e dell'Emilia Romagna, Brescia, 25124, Italy.
Porcine Reproductive and Respiratory Syndrome (PRRS) causes huge economic losses to pig farms worldwide. Currently available vaccines do not always offer complete protection, due to the extreme variability of the virus. Therefore, good farming practices must be improved to prevent the disease from spreading across the pig production system.
View Article and Find Full Text PDFOrphanet J Rare Dis
December 2024
Department of Physical Medicine and Rehabilitation, Facultad de Medicina, Universidad Nacional de Colombia, Carrera 30 No.45-03. Edificio 471, Piso 5to, Of. 513-A, Bogotá, Colombia.
Background: Hereditary transthyretin amyloidosis (hATTR) is a rare autosomal dominant disease with high clinical variability, influenced by both genotype and the geographic origins of carriers. There is a limited understanding of the Val142Ile and Ser43Asn recognised mutations in Ecuador and Colombia. Therefore, the objective of this study is to describe the neurological and functional characteristics of patients with hATTR associated with the Val142Ile and Ser43Asn mutations, as well as to identify possible differentiating factors between the two mutations.
View Article and Find Full Text PDFJ Appl Anim Welf Sci
December 2024
Department of Integrative Biology, University of Guelph, Guelph, ON, Canada.
Animal shelters address animal welfare in communities through the intake and outcome of companion animals, but these efforts affect population dynamics of companion animals based on the distance animals are moved and the factors that underlie intake and outcome. Using data from an animal shelter in Washington, DC we analyzed cat intakes and outcomes based on geographic and socioeconomic factors. Most intakes were stray cats (59%) and cats relinquished by owners (38%) and most outcomes were adoptions (84%).
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