Fully automated dual-run manufacturing of [C]PIB on FASTlab.

This report describes an updated, fully automated method for the production of [C]PIB on a cassette-based automated synthesis module. The method allows for two separate productions of [C]PIB, both of which meet all specification for use in clinical studies. The GE FASTlab developer system was used to create the cassette design as well as the controlling tracer package. The method takes 16 min from the delivery of [C]MeOTf to the FASTlab, or 35 min from the End of Bombardment; and reliably produces 3547 ± 586 MBq of [C]PIB in high radiochemical purity (> 98 %). This methodology increases the production capacity of radiopharmaceutical facilities for [C]PIB, and can easily produce 4 batches in a single day with limited infrastructure footprint.