in vitro in vivo
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Development studies on the orodispersible freeze-dried platforms for lurasidone hydrochloride - Understanding the effect of amino acid additive and lyophilization stage.
Int J Pharm
December 2024
Department of Pharmaceutical Technology, Medical University of Białystok, Mickiewicza 2c, 15-222 Bialystok, Poland. Electronic address:
In this study, lyophilizates with the second-class antipsychotic agent lurasidone hydrochloride were developed as orodispersible platforms to improve patients' adherence. The primary aim was to evaluate the effect of the amino acid additive (L-arginine, L-lysine, L-histidine) and the freeze-drying stage on the pharmaceutical performance of the designed formulations. The composition was initially optimized using an experimental design approach.
View Article and Find Full Text PDFNanomolar detection of lurasidone hydrochloride in pharmaceutical formulations (Serodopamoun®) and spiked urine using a PVC/imprinted polymer/MWCNTs layer deposited onto polyaniline-coated screen-printed electrodes.
RSC Adv
December 2024
Department of Chemistry, Faculty of Science, Cairo University 12613 Giza Egypt
This study developed potentiometric sensors for detecting lurasidone HCl (LSH), a vital drug for treating schizophrenia and bipolar I disorder, in pharmaceutical formulations and biological samples. The sensors are based on screen-printed electrodes (SPE) modified with a molecularly imprinted polymer (MIP) synthesized using lurasidone as a template, 1-vinyl-2-pyrrolidine (VP) as a functional monomer, ethylene glycol dimethacrylate (EGDMA) as a crosslinker, and benzoyl peroxide as an initiator. The SPE was further modified with a conductive polyaniline (PANI) film and a polyvinyl chloride (PVC) layer containing MIP as an ionophore and multiwalled carbon nanotubes (MWCNT) as a transducing material along with 2-nitrophenyl octyl ether (2-NPOE) as plasticizer.
View Article and Find Full Text PDFEfficacy and acceptability of lurasidone for bipolar depression: a systematic review and dose-response meta-analysis.
BMJ Ment Health
November 2024
Institute of Health Data Analytics & Statistics, College of Public Health, National Taiwan University, Taipei, Taiwan.
Article Synopsis
- The study researched the optimal dose of lurasidone for treating bipolar depression, focusing on efficacy, acceptability, and metabolic/endocrine effects.
- It reviewed five clinical trials involving 2,032 patients and found that doses between 40-60 mg significantly improved depression, anxiety, and quality of life while experiencing manageable side effects.
- Results indicated that while higher doses led to increased side effects and weight gain, a 40-60 mg dose was generally the best choice for treatment without major risks of dropout or manic switch.
The potential of supramolecular synthon to develop coamorphous systems with tailored physical stability: Mechanistic insights integrating kinetics and thermodynamics.
Int J Pharm
December 2024
School of Traditional Chinese Pharmacy, China Pharmaceutical University, Nanjing 211198, PR China. Electronic address:
Coamorphous drug delivery systems have received increasing interest owing to their potential to improve the solubility, dissolution and bioavailability of poorly water-soluble drugs. However, the crystallization risk is one of major limitations in their application. It has been widely recognized that the coformer plays a vital role in physical stability of coamorphous formulation.
View Article and Find Full Text PDFProminently selective fluorescence approach with distinctive biopharmaceutical utility for analysis of lurasidone in human plasma and urine: Application to in vitro dissolution and content uniformity testing.
Luminescence
September 2024
Department of Pharmaceutical Analytical Chemistry, Faculty of Pharmacy, Mansoura University, Mansoura, Egypt.
A relevant approach based on the attractive inherited merits of fluorescence spectroscopy has been established for quantitative estimation of a newly approved second-generation atypical antipsychotic lurasidone (LUR) in its raw materials and pharmaceutical dosage forms. This study brings to light the strong native fluorescence of LUR at 400 nm in water after excitation at 316 nm. Different experimental parameters that may compromise the fluorescence of the drug were carefully investigated and optimized.
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