Importance: The associations of low-carbohydrate diets (LCDs) with long-term weight management remains unclear, and the source and quality of macronutrients within LCDs are less explored.

Objectives: To prospectively examine associations between changes in LCD indices and weight change among US adults.

Design, Setting, And Participants: This prospective cohort study included initially healthy participants at baseline from the Nurses' Health Study (NHS; 1986-2010), Nurses' Health Study II (NHSII; 1991-2015), and Health Professionals Follow-up Study (HPFS; 1986-2018). Data analysis was performed between November 2022 and April 2023.

Exposures: Five LCD indices were examined: (1) a total LCD (TLCD) emphasizing overall lower carbohydrate intake; (2) an animal-based LCD (ALCD) that emphasized animal-sourced protein and fat; (3) a vegetable-based LCD (VLCD) that emphasized plant-sourced protein and fat; (4) a healthy LCD (HLCD) emphasizing less refined carbohydrates, more plant protein, and healthy fat; and (5) an unhealthy LCD (ULCD) emphasizing less healthful carbohydrates, more animal protein, and unhealthy fat.

Main Outcomes And Measures: The outcome of interest was 4-year changes in self-reported body weight.

Results: A total of 123 332 participants (mean [SD] age, 45.0 [9.7] years; 103 320 [83.8%] female) were included in this study. The median carbohydrate intake (as a percentage of energy) of the highest quintiles of TLCD score at baseline ranged from 38.3% in HPFS to 40.9% in NHSII. Mean weight gain over 4-year intervals among participants varied from 0.8 kg in the HPFS to 1.8 kg in the NHSII. After adjusting for demographics and baseline and concomitant changes of selected lifestyle factors, each 1-SD increase in TLCD score was associated with 0.06 (95% CI, 0.04-0.08) kg more weight gain over the 4-year periods. Similarly, participants gained 0.13 (95% CI, 0.11 to 0.14) kg per each 1-SD increase in ALCD score and 0.39 (95% CI, 0.37 to 0.40) kg per each 1-SD change in ULCD score. In contrast, each 1-SD increase in VLCD score was associated with 0.03 (95% CI, 0.01 to 0.04) kg less weight gain, and each 1-SD increase in HLCD score was associated with 0.36 (95% CI, 0.35 to 0.38) kg less weight gain. The associations were more pronounced among obese individuals (per 1-SD increase in HLCD score: BMI ≥30, 0.88 [95% CI, 0.80, 0.97] kg less weight gain; BMI <25, 0.23 [95% CI, 0.20, 0.26] kg less weight gain; P for interaction < .001).

Conclusions And Relevance: These findings suggest that the quality of LCDs may play a critical role in modulating long-term weight change. Only LCDs that emphasized high-quality protein, fat, and carbohydrates from whole grains and other plant-based foods were associated with less weight gain.

Download full-text PDF

Source
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC10753393PMC
http://dx.doi.org/10.1001/jamanetworkopen.2023.49552DOI Listing

Publication Analysis

Top Keywords

weight gain
20
1-sd increase
20
score associated
12
weight
8
weight change
8
lcd indices
8
nurses' health
8
health study
8
carbohydrate intake
8
protein fat
8

Similar Publications

Genetic parameters and correlations between growth traits and packed cell volume of N'Dama cattle in the Gambia.

Trop Anim Health Prod

December 2024

Animal Breeding and Genomic Group, Department of Animal Science, University Egerton, PO Box 536-20115, Egerton, Kenya.

The evolution of body weight under the natural trypanosome challenge and its association with disease tolerance to trypanosomosis is of utmost economic importance in cattle. This study estimated heritability for growth traits and packed cell volume (PCV) and their genetic correlations in the N'Dama cattle in the Gambia. A total of 2,488, 2,442, 1,471, 1,934, and 1,452 bodyweight records at 12 months (WT12), 16 months (WT16), 18 months (WT18), 24 months (WT24), 36 months (WT36) and 50 months (WT50) and 1,782, 1,800, 1,844, 1,608, and 1,459 records for PCV at 12 months (PCV12) 18 months (PCV18), 24 months (PCV24), 36 months (PCV36), and 50 months (PCV50), respectively, were analysed.

View Article and Find Full Text PDF

The effects of incorporating Illipe nut into the diet of pigs, in replacement of yellow maize, on their growth performance and meat quality was investigated in a 60 days feeding trial. Twenty-four male pigs were divided into two treatments and fed diets with 0% (T1) or 15% (T2) Illipe nut inclusion. Feed intake, live weight (LW) and backfat thickness (BFT) were taken and used to calculate average daily feed intake (ADFI), average daily gain (ADG), feed conversion ratio (FCR) and increase in backfat (IBF).

View Article and Find Full Text PDF

Background: In recent years, the use of music as a therapeutic and developmental tool for infants, especially within neonatal intensive care units (NICUs), has seen a surge in interest. Despite a growing body of research underscoring the potential benefits of music therapy and music medicine in enhancing infant development and aiding medical practices, the specific characteristics of music that maximize these benefits remain poorly understood.

Objectives: This scoping review aims to provide a comprehensive foundation by mapping the existing literature on passive music listening and identifying gaps, trends, and patterns that are crucial precursors to the development of best practices.

View Article and Find Full Text PDF

Objective Few reports have examined the association between "weight gain since the past combined with the presence of obesity" and diabetes mellitus (DM). Therefore, we longitudinally examined the influence of the combination of "weight gain of ≥10 kg since the age of 20 years" and the presence of obesity on the new onset of DM.Methods We identified 8,704 National Health Insurance enrollees in Habikino City, Osaka Prefecture, who underwent specific health checkups in 2013.

View Article and Find Full Text PDF

Want AI Summaries of new PubMed Abstracts delivered to your In-box?

Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!