AI Article Synopsis
- There is a reciprocal relationship between diabetes mellitus and periodontitis, where each condition can worsen the other.
- Certain immune and inflammatory responses are heightened in patients with both diabetes and periodontitis, involving similar biological factors.
- The review highlights potential biomarkers, including specific microbes and immune mediators, which could aid in diagnosing and treating these two interconnected health issues.
Article Abstract
It has been well documented that there is a two-way relationship between diabetes mellitus and periodontitis. Diabetes mellitus represents an established risk factor for chronic periodontitis. Conversely, chronic periodontitis adversely modulates serum glucose levels in diabetic patients. Activated immune and inflammatory responses are noted during diabetes and periodontitis, under the modulation of similar biological mediators. These activated responses result in increased activity of certain immune-inflammatory mediators including adipokines and microRNAs in diabetic patients with periodontal disease. Notably, certain microbes in the oral cavity were identified to be involved in the occurrence of diabetes and periodontitis. In other words, these immune-inflammatory mediators and microbes may potentially serve as biomarkers for risk assessment and therapy selection in diabetes and periodontitis. In this review, we briefly provide an updated overview on different potential biomarkers, providing novel diagnostic and therapeutic insights on periodontal complications and diabetes mellitus.
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| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC10750125 | PMC |
| http://dx.doi.org/10.3389/fendo.2023.1292596 | DOI Listing |
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