Vascular co-option in resistance to anti-angiogenic therapy.

Front Oncol

Department of Translational Biomedicine and Neuroscience, University of Bari Medical School, Bari, Italy.

Published: December 2023

Three different mechanisms of neovascularization have been described in tumor growth, including sprouting angiogenesis, intussusceptive microvascular growth and glomeruloid vascular proliferation. Tumors can also grow by means of alternative mechanisms including vascular co-option, vasculogenic mimicry, angiotropism, and recruitment of endothelial precursor cells. Vascular co-option occurs in tumors independently of sprouting angiogenesis and the non-angiogenic cancer cells are described as exploiting pre-existing vessels. Vascular co-option is more frequently observed in tumors of densely vascularized organs, including the brain, lung and liver, and vascular co-option represents one of the main mechanisms involved in metastasis, as occurs in liver and lung, and resistance to anti-angiogenic therapy. The aim of this review article is to analyze the role of vascular co-option as mechanism through which tumors develop resistance to anti-angiogenic conventional therapeutic approaches and how blocking co-option can suppress tumor growth.

Download full-text PDF

Source
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC10750409PMC
http://dx.doi.org/10.3389/fonc.2023.1323350DOI Listing

Publication Analysis

Top Keywords

vascular co-option
24
resistance anti-angiogenic
12
anti-angiogenic therapy
8
tumor growth
8
sprouting angiogenesis
8
vascular
7
co-option
6
co-option resistance
4
therapy three
4
three mechanisms
4

Similar Publications

Want AI Summaries of new PubMed Abstracts delivered to your In-box?

Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!