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PFSH-Net: Parallel frequency-spatial hybrid network for segmentation of kidney stones in pre-contrast computed tomography images of dogs.

Comput Biol Med

January 2025

Division of Electronics and Information Engineering, College of Engineering, Jeonbuk National University, 567, Baekje-daero, Deokjin-gu, 54896, Jeonju, Republic of Korea. Electronic address:

Kidney stone is a common urological disease in dogs and can lead to serious complications such as pyelonephritis and kidney failure. However, manual diagnosis involves a lot of burdens on radiologists and may cause human errors due to fatigue. Automated methods using deep learning models have been explored to overcome this limitation.

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Gastrointestinal tract-related cancers pose a significant health burden, with high mortality rates. In order to detect the anomalies of the gastrointestinal tract that may progress to cancer, a video capsule endoscopy procedure is employed. The number of video capsule endoscopic ( ) images produced per examination is enormous, which necessitates hours of analysis by clinicians.

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Background: Artificial intelligence (AI) models are emerging as promising tools to identify predictive features among data coming from health records. Their application in clinical routine is still challenging, due to technical limits and to explainability issues in this specific setting. Response to standard first-line immunotherapy (ICI) in metastatic Non-Small-Cell Lung Cancer (NSCLC) is an interesting population for machine learning (ML), since up to 30% of patients do not benefit.

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Accurate diagnosis of pancreatic cancer using CT scan images is critical for early detection and treatment, potentially saving numerous lives globally. Manual identification of pancreatic tumors by radiologists is challenging and time-consuming due to the complex nature of CT scan images and variations in tumor shape, size, and location of the pancreatic tumor also make it challenging to detect and classify different types of tumors. Thus, to address this challenge we proposed a four-stage framework of computer-aided diagnosis systems.

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Background: Apolipoprotein E (ApoE) exhibits isoform-specific interactions with Alzheimer's disease (AD)-related pathology. In comparison with the more common ApoE3 isoform, ApoE4 promotes amyloid-β (Aβ) deposition, enhances tau-mediated neurodegeneration and inflammation. However, the lack of appropriate preclinical models has limited the ability to evaluate the potential synergistic effect of Aβ, tau and ApoE on cognition and disease progression.

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