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| http://dx.doi.org/10.1002/clt2.12309 | DOI Listing |
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Incidence of Alpha-Gal IgE Sensitization in 3000 Military Personnel, Assessing Sex, Race, Installation, and Occupational Impacts.
J Clin Med
November 2024
Department of Pediatrics, Uniformed Services University of the Health Sciences, Bethesda, MD 20814, USA.
: IgE to galactose-alpha-1,3-galactose (alpha-gal) is associated with (lone star tick) bites, accounting for the regional distribution of the alpha-gal syndrome (AGS). Longitudinal studies describing risk factors for incident alpha-gal sensitization are lacking. The objective of this project was to assess the incidence of alpha-gal IgE seroconversion and identify associated demographic, occupational, and geographical risk factors among US military personnel.
View Article and Find Full Text PDFSensitization to α-gal and omega-5-gliadin in patients with chronic urticaria: clinical implications and need for targeted testing.
Postepy Dermatol Alergol
October 2024
Special Hospital for Pulmonary Diseases, Zagreb, Croatia.
Introduction: Chronic urticaria (CU) is defined as the presence of recurring hives and/or angioedema lasting more than 6 weeks. The precise impact of food allergies, particularly to galactose-α-1,3-galactose (α-gal) and omega-5-gliadin (O5G), on the development of CU is not well established.
Aim: The study examines the frequency of sensitisation to these allergens and their clinical significance in individuals with CU.
Is gastrointestinal epithelial barrier dysfunction the only responsible for sensitization to food allergens?
Eur Ann Allergy Clin Immunol
November 2024
Clinical and Laboratory Molecular Allergy Unit, Fondazione Luigi Maria Monti, IDI-IRCCS, Rome, Italy.
Article Synopsis
- Epithelial barriers are vital for protecting against pathogens and allergens, and when environmental factors compromise them, conditions like asthma and food allergies can arise.
- While the dysfunction of skin and respiratory barriers in allergies is well-established, the gut epithelium's role in food allergies is less clear, as it usually maintains integrity and fosters immune tolerance through specific immune mechanisms.
- Research indicates that certain food allergies, such as those to cow's milk and hen's egg, often resolve with age, and studies like the LEAP trial suggest that early allergen exposure can help prevent allergies, showcasing the complex nature of allergen sensitization beyond just food intake.
Longitudinal Follow-up Reveals Peripheral Immunological Changes Upon Tick Bite in a-Gal-Sensitized Individuals.
J Investig Allergol Clin Immunol
November 2024
Department of Infection and Immunity, Luxembourg Institute of Health, Esch-sur-Alzette, Luxembourg.
Background And Objectives: α-Gal syndrome is characterized by specific IgE (sIgE) antibodies to the carbohydrate galactose-α-1,3-galactose (α-Gal) and delayed onset of allergic symptoms after ingestion of mammalian meat. While tick bites are assumed to mediate sensitization, the immune response to tick bites has not yet been investigated. To investigate the peripheral immune response to tick bites in humans over time.
View Article and Find Full Text PDFIncreasing prevalence of galactose-α-1,3-galactose sensitization in the Danish general adult population.
Allergy
January 2025
Center for Clinical Research and Prevention, Copenhagen University Hospital-Bispebjerg and Frederiksberg, Copenhagen, Denmark.
Background: Alpha-gal syndrome is a novel food allergy to the oligosaccharide galactose-α-1,3-galactose (alpha-gal) present in mammalian meat. Tick bites are considered an important route of sensitization to alpha-gal. Data on alpha-gal sensitization in the general population is scant.
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