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A new benzophenanthridine alkaloid from stem bark of and its biological activities. | LitMetric
A new benzophenanthridine alkaloid 6-butanoyldihydrochelerythrine and five known alkaloids 6-acetonyldihydronitidine , 6-acetonyldihydrochelerythrine , isocorydine , (O)-methyltembamide , N-(4-methoxyphenethyl)benzamide were isolated from the stem barks of . These structures were elucidated by 1D, 2D NMR spectroscopy and by mass spectrometry. This is the first time that compounds were identified from and the first time that compounds and were identified from the genus . Bioactivity results of isolated compounds showed that , , and exhibited inhibitory activity against MCF7 and A549 cell lines, while showed the inhibitory activity against A549 cell line; all isolated compounds - inhibited at least two strain microorganisms; compound showed angiotensin II converting enzyme inhibitory activity with IC value of 65.58 µM and with a docking score of -11.52 kcal/mol.
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