AI Article Synopsis
- Orthopedic implants are crucial for treating musculoskeletal issues, enhancing patients' quality of life, with diverse biocomposites being explored for various medical applications.
- Polyimide (PI) is a strong and biocompatible material with bone-like elasticity, but lacks necessary bioactivity for effective cell adhesion and bone regeneration.
- By applying tantalum pentoxide (TaO) coating on PI using polydopamine bonding, researchers improved the surface properties of PI, which encouraged bone cell growth and suggested better potential for PI in bone repair.
Article Abstract
Orthopedic implants are an important tool in the treatment of musculoskeletal conditions and helped many patients to improve their quality of life. Various inorganic-organic biocomposites have been broadly investigated particularly in the area of load-bearing orthopedic/dental applications. Polyimide (PI) is a promising organic material and shows excellent mechanical properties, biocompatibility, bio-stability, and its elastic modulus is similar to human bone but it lacks bioactivity, which is very important for cell adhesion and ultimately for bone regeneration. In this research, tantalum pentoxide (TaO) coating was prepared on the surface of PI by polydopamine (PDA) bonding. The results showed that TaO was evenly coated on the surface of PI, and with the concentration of TaO in the PDA suspension increased, the content of TaO particles on the surface of PI increased significantly. In addition, the TaO coating significantly increased the roughness and hydrophilicity of the PI matrix. Cell experiments showed that PI surface coating TaO could promote the proliferation, adhesion, and osteogenic differentiation of bone marrow-derived stromal cells (BMSCs). The results demonstrated that fabricating TaO coating on the surface of PI through PDA bonding could improve the biocompatibility as well as bioactivity of PI, and increase the application potential of PI in the field of bone repair materials.
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|---|---|
| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC10746511 | PMC |
| http://dx.doi.org/10.1016/j.heliyon.2023.e23284 | DOI Listing |
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