AI Article Synopsis
- Cardiac aging makes the heart weaker and can lead to serious heart diseases, so it's important to find ways to slow this process down.
- This study looked at how a substance called parishin, from traditional Chinese medicine, helps prevent heart aging by testing it on young and old mice.
- The results showed that parishin improved heart health, reduced damage from aging, and helped with some harmful markers in the heart, suggesting it may also benefit gut health.
Article Abstract
Background: Cardiac aging progressively decreases physiological function and drives chronic/degenerative aging-related heart diseases. Therefore, it is crucial to postpone the aging process of heart and create products that combat aging.
Aims & Methods: The objective of this study is to examine the effects of parishin, a phenolic glucoside isolated from traditional Chinese medicine , on anti-aging and its underlying mechanism. To assess the senescent biomarkers, cardiac function, cardiac weight/body weight ratio, cardiac transcriptomic changes, and cardiac histopathological features, heart tissue samples were obtained from young mice (12 weeks), aged mice (19 months) treated with parishin, and aged mice that were not treated.
Results: Parishin treatment improved cardiac function, ameliorated aging-induced cardiac injury, hypertrophy, and fibrosis, decreased cardiac senescence biomarkers p16, p21, and IL-6, and increased the "longevity factor" SIRT1 expression in heart tissue. Furthermore, the transcriptomic analysis demonstrated that parishin treatment alleviated the cardiac aging-related downregulation and and upregulation in the heart tissues. The correlation analysis suggested a strong connection between the anti-aging effect of parishin and its regulation of gut microbiota and metabolism in the aged intestine.
Conclusion: The present study demonstrates the protective role and underlying mechanism of parishin against cardiac aging in naturally aged mice.
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| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC10746429 | PMC |
| http://dx.doi.org/10.1016/j.heliyon.2023.e22970 | DOI Listing |
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