Peripartum Cardiomyopathy is a rare type of cardiomyopathy that occurs during late pregnancy or in early postpartum period and is a life threatening condition. It presents with heart failure secondary to left ventricular systolic dysfunction. Here the LVEF is < 45%, with/without LV dilatation. The condition shows overlapping symptoms with pregnancy related pathology like preeclampsia, myocarditis or underlying genetic diseases and hence underestimated. Underlying pathophysiology is poorly understood with lack of specific biomarkers. Timely diagnosis and multidisciplinary team approach helps in determining the outcome.
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http://dx.doi.org/10.1007/s13224-023-01872-7 | DOI Listing |
Nat Commun
January 2025
Sree Chitra Tirunal Institute for Medical Sciences and Technology (SCTIMST), Trivandrum, India.
Survival outcomes of patients with heart failure (HF) based on their disease etiology are not well described. Here, we provide one-year mortality outcomes of 10850 patients with HF (mean age = 59.9 years, 31% women) in India.
View Article and Find Full Text PDFCirc Res
January 2025
Department of Integrative Pathophysiology, Medical Faculty Mannheim, DZHK Partnersite Mannheim-Heidelberg, University of Heidelberg, Germany (S.L.).
This review examines the giant elastic protein titin and its critical roles in heart function, both in health and disease, as discovered since its identification nearly 50 years ago. Encoded by the TTN (titin gene), titin has emerged as a major disease locus for cardiac disorders. Functionally, titin acts as a third myofilament type, connecting sarcomeric Z-disks and M-bands, and regulating myocardial passive stiffness and stretch sensing.
View Article and Find Full Text PDFKardiol Pol
December 2024
Department of Cardiology, Rigshospitalet, Copenhagen, Denmark.
Cardiogenic shock (CS) in women is a serious cardiovascular (CV) event associated with a high mortality rate. Non-ischemic etiologies are the most common etiologies in women, such as stress-induced cardiomyopathy, peripartum/postpartum cardiomyopathy, heart failure-related CS, or CS due to myocarditis or valvular heart disease. Although not being the most common etiology in women, acute myocardial infarction is still an important one.
View Article and Find Full Text PDFInt J Cardiol Congenit Heart Dis
September 2024
Adult Congenital Heart Diseases Unit, Royal Brompton Hospital, London, UK.
Peripartum cardiomyopathy (PPCM) is a rare, but serious condition, with a non-negligible risk of adverse events. Several risk factors for PPCM have been individuated over the years, including Afro-American ethnicity, preeclampsia, advanced maternal age, genetic predisposition, multiparity, twin pregnancy, obesity, smoking and diabetes. However, PPCM pathophysiology is still poorly understood, thus making it challenging to develop disease specific therapies.
View Article and Find Full Text PDFJACC Case Rep
December 2024
Division of Cardiology, Baylor Scott and White Health-Temple, Temple, Texas, USA.
Management of peripartum cardiomyopathy and cardiogenic shock often presents a significant clinical challenge. These patients are frequently best served at a specialized center with access to cardiac anesthesia, maternal-fetal medicine, and cardiac intensivists. Planning for delivery involves a plan for anesthesia and management of hemodynamic changes during the postoperative period.
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