AI Article Synopsis
- Despite extensive research, the exact cause of Alzheimer's disease (AD) is still unknown, leading to a new hypothesis focusing on the enzyme carnitine palmitoyl transferase-2 (CPT2) as a key player in the disease.
- CPT2, found in the inner mitochondrial membrane, is vital for fatty acid metabolism and is particularly sensitive to hydrogen peroxide, which is produced in excess by major AD risk factors.
- The inhibition of CPT2 due to increased hydrogen peroxide levels may contribute to the symptoms of AD, offering new insights for potential therapeutic strategies.
Article Abstract
Despite decades of intense research, the precise etiology of Alzheimer's disease (AD) remains unclear. In this hypothesis, we present a new perspective on this matter by identifying carnitine palmitoyl transferase-2 (CPT2) as a central target in AD. CPT2 is an enzyme situated within the inner mitochondrial membrane, playing a crucial role in beta-oxidation of fatty acids. It exhibits high sensitivity to hydrogen peroxide. This sensitivity holds relevance for the etiology of AD, as all major risk factors for the disease share a commonality in producing an excess of hydrogen peroxide right at this very mitochondrial membrane. We will explain the high sensitivity of CPT2 to hydrogen peroxide and elucidate how the resulting inhibition of CPT2 can lead to the characteristic phenotype of AD, thus clarifying its central role in the disease's etiology. This insight holds promise for the development of therapies for AD which can be implemented immediately.
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| http://dx.doi.org/10.3233/JAD-230991 | DOI Listing |
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