Three new compounds from the seeds of L.

Nat Prod Res

First Clinical Medical College, Shandong University of Traditional Chinese Medicine, Department of Endocrinology and Metabology, Shandong Provincial Qianfoshan Hospital, Shandong Key Laboratory of Rheumatic Disease and Translational Medicine, Shandong Institute of Nephrology, Jinan, China.

Published: December 2023

Three undescribed compounds, 1-(4-hydroxyphenyl)-3-((4-hydroxyphenyl)thio) -2-propanone (), 4'-hydroxybenzyl 4-(4''- hydroxybenzyloxy) benzyl thioether () and 3-(4'-hydroxybenzyl)-6-hydroxy-quinazolinone () were isolated from the seeds of L. The structures of all compounds were elucidated based on NMR and MS analysis, along with the comparison with published data. The potential targets of compounds - were identified by virtual screening. The potential inhibitory effects of these compounds on protein kinase C theta type were compared by molecular docking. The docking score of compound was the highest.

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Source
http://dx.doi.org/10.1080/14786419.2023.2297402DOI Listing

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