Acute or chromic bleeding, such as epistaxis, requires hemostatic materials to assist hemostasis. Even in complex cases, hemostatic materials must have other functions, including the promotion of healing and prevention of adhesion. Herein, a series of fibrosis-suppressive functional cRGD-modified crosslinking hyaluronic acid sponges were prepared. The in vitro hemostatic efficiency and mechanism were determined using blood clotting time, blood coagulation index, lactate dehydrogenase (LDH) and thromboxane B2 (TX-B2) ELISA, and proteomics. Among the prepared sponges, both poly(ethylene-b-L-Phe) (PEBP)-and cRGD contained SPN4 and exhibited the highest platelet concentration and activation efficiency as well as the most effective coagulative effect. In addition, no significant cytotoxicity was observed for the sponges in rat airway epithelial cells. The in vivo hemostatic and adhesion-preventive effects of the sponges were evaluated using rat models of liver injury and sidewall defect-cecum abrasion. PEBP-containing sponges effectively prevented postoperative adhesion and cRGD-modified sponges exhibited excellent hemostatic effects. Finally, the comprehensive repair effects of the sponges were evaluated using a rabbit maxillary sinus mucosal injury model, based on CT, MRI examination, and pathological staining. SPN4 exhibited the best comprehensive reparative effects, including the promotion of mucosal repair and infection inhibition. Thus, SPN4 is a promising multifunctional hemostatic material.
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http://dx.doi.org/10.1016/j.ijbiomac.2023.128911 | DOI Listing |
Rev Esp Enferm Dig
January 2025
Hepatobiliary Pancreatic Surgery, Jiaozhou Branch of Shanghai East Hospital.
Background: Long non-coding RNAs (lncRNAs) are major research factors in a variety of diseases, and lncRNA OIP5-AS1 (OIP5-AS1) was shown to mediate the progression of various tumors. This paper discusses how OIP5-AS1 could potentially be used for diagnosing and prognosticating cholangiocarcinoma (CHOL).
Methods: The ENROCI project evaluated the OIP5-AS1 expression in CHOL samples and confirmed it using RT-qPCR.
Alzheimers Dement
December 2024
Quality Compliance Systems, High Wycombe, NA, United Kingdom.
Background: An important aspect of quality of life is engagement in meaningful and purposeful activities. For people living with dementia (PLwD), opportunities to engage in purposeful activities can be vastly diminished. Successful engagement of individuals with dementia typically hinges upon selecting engagement targets and activities that are appropriate to the individual's level of cognitive functioning.
View Article and Find Full Text PDFAsian Cardiovasc Thorac Ann
January 2025
Departments of Cardiac Surgery, HMC, Doha, Qatar.
Bombay blood (hh blood) is a rare blood group (4 per million), with no expression of the H antigen present in blood group O. Bombay blood patients can only receive Bombay blood, with autodonation used for elective surgery. We present a Bombay patient (haemoglobin 12.
View Article and Find Full Text PDFChem Biodivers
January 2025
SRM Institute of Science and Technology: SRM Institute of Science and Technology (Deemed to be University), Department of Chemical Engineering, Kattankulathur, 603203, Chengalpattu, INDIA.
The rising threat of antimicrobial resistance among pathogens highlights the critical need for novel antimicrobial agents. This study explores the potential of natural products by investigating hexane extracts from the marine sponge Haliclona fibulata (HF) for their antibacterial efficacy. The well diffusion method of HF extract showed significant antibacterial activity against P.
View Article and Find Full Text PDFJ Orthop Surg Res
January 2025
Department of Orthopedics, The Affiliated Suqian First People's Hospital of Nanjing Medical University, Suqian, 223800, Jiangsu, China.
Background: Osteoarthritis (OA) is a common type of degenerative arthropathy. Previous studies have demonstrated that circular RNAs (circRNAs) are involved in the progression of OA. This study aimed to investigate the role and associated mechanism of circ_0075048 in OA.
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