Purpose: 68 Ga-citrate PET/CT imaging in the diagnosis of skull base osteomyelitis (SBO) and its usefulness in the assessment of treatment response.
Methods: Eighteen patients underwent 68 Ga-citrate PET/CT scans for suspected SBO for diagnosis/assessment of treatment response.
Results: Of 18 patients, 16 patients had a positive study for SBO, and 2 patients had a negative study. Scan findings were correlated with clinical, biochemical, microbiological, and radiological parameters.
Conclusion: 68 Ga-citrate PET/CT is a promising tool in the diagnosis and management of skull base osteomyelitis.
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http://dx.doi.org/10.1097/RLU.0000000000004904 | DOI Listing |
Clin Nucl Med
February 2024
Otorhinolaryngology, Christian Medical College, Vellore, India.
Purpose: 68 Ga-citrate PET/CT imaging in the diagnosis of skull base osteomyelitis (SBO) and its usefulness in the assessment of treatment response.
Methods: Eighteen patients underwent 68 Ga-citrate PET/CT scans for suspected SBO for diagnosis/assessment of treatment response.
Results: Of 18 patients, 16 patients had a positive study for SBO, and 2 patients had a negative study.
Clin Microbiol Infect
March 2024
Department of Internal Medicine, Radboud University Medical Center, Nijmegen, The Netherlands.
Background: Fever of unknown origin (FUO) and inflammation of unknown origin (IUO) are diagnostic challenges that often require an extensive work-up. When first-line tests do not provide any or only misleading clues, second-line investigations such as specialized imaging techniques are often warranted.
Objectives: To provide an overview of the diagnostic value of imaging techniques that are commonly used in patients with FUO/IUO.
Nucl Med Rev Cent East Eur
March 2023
Department of Nuclear Medicine, Sotiria General Hospital, Athens, Greece.
A cold vertebral defect is an uncommon finding, especially in Gallium-67-citrate ([67Ga]Ga-citrate) - and [18F]fluorodeoxyglucose ([18F]FDG) - avid lymphomas, representing a diagnostic challenge. Here, we present the case of a patient with non-Hodgkin lymphoma (NHL), in whom the [67Ga]Ga-citrate and [18F]FDG scans showed a diffuse skeletal uptake pattern with concomitant appearance of a cold vertebral defect. Awareness of the different causes of such uptake patterns and accurate clinical information is important to avoid misinterpretation of nuclear studies in oncologic patients.
View Article and Find Full Text PDFCancers (Basel)
September 2022
Department of Nuclear Medicine, The First Affiliated Hospital of Sun Yat-Sen University, Zhongshan Er Road, Guangzhou 510030, China.
High-dose vitamin C (VC) exhibits anti-tumor effects, and the cytotoxicity of VC is correlated with oxidative stress. However, iron, as a redox metal, plays an important effect in redox cycling and free radical formation in cells. This study addresses the role of iron ion in the cytotoxicity of VC.
View Article and Find Full Text PDFSemin Nucl Med
January 2023
Medical Imaging Center, Department of Nuclear Medicine and Molecular Imaging, University of Groningen, University Medical Center Groningen, Groningen, The Netherlands.
F-FDG PET/CT, Ga-citrate and white blood cell (WBC) scintigraphy are molecular imaging techniques currently used in the diagnostic workup of fever of unknown origin. However, it is unknown which technique fits which patient group best. A systematic literature search has been performed for original articles regarding the use of molecular imaging in fever of unknown origin.
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