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Poly(ethylene Glycol) Methyl Ether Methacrylate-Based Injectable Hydrogels: Swelling, Rheological, and In Vitro Biocompatibility Properties with ATDC5 Chondrogenic Lineage. | LitMetric

Poly(ethylene Glycol) Methyl Ether Methacrylate-Based Injectable Hydrogels: Swelling, Rheological, and In Vitro Biocompatibility Properties with ATDC5 Chondrogenic Lineage.

Polymers (Basel)

Servizo Galego de Saude (SERGAS) and Instituto de Investigación Sanitaria de Santiago (IDIS), Neuroendocrine Interactions in Rheumatology and Inflammatory Diseases (NEIRID Group), Santiago University Clinical Hospital, Building C, Travesía da Choupana S/N, 15706 Santiago de Compostela, Spain.

Published: December 2023

AI Article Synopsis

  • The study focuses on creating injectable hydrogels using polyethylene glycol methyl ether methacrylate (PEGMEM) and 2-dimethylamino ethyl methacrylate (DMAEM), examining how their components affect swelling, rheological properties, and biocompatibility.
  • The hydrogels were made through free radical polymerization, with findings showing that swelling and mechanical properties depended on the amounts of monomer, catalyst, and crosslinker used.
  • The results indicated that while homopolymeric hydrogels showed no toxicity, copolymeric hydrogels could be toxic at high DMAEM levels and that certain crosslinkers may trigger inflammation, hinting at their potential applications in cartilage regeneration.

Article Abstract

Here, we present the synthesis of a series of chemical homopolymeric and copolymeric injectable hydrogels based on polyethylene glycol methyl ether methacrylate (PEGMEM) alone or with 2-dimethylamino ethyl methacrylate (DMAEM). The objective of this study was to investigate how the modification of hydrogel components influences the swelling, rheological attributes, and in vitro biocompatibility of the hydrogels. The hydrogels' networks were formed via free radical polymerization, as assured by H nuclear magnetic resonance spectroscopy (H NMR). The swelling of the hydrogels directly correlated with the monomer and the catalyst amounts, in addition to the molecular weight of the monomer. Rheological analysis revealed that most of the synthesized hydrogels had viscoelastic and shear-thinning properties. The storage modulus and the viscosity increased by increasing the monomer and the crosslinker fraction but decreased by increasing the catalyst. MTT analysis showed no potential toxicity of the homopolymeric hydrogels, whereas the copolymeric hydrogels were toxic only at high DMEAM concentrations. The crosslinker polyethylene glycol dimethacrylate (PEGDMA) induced inflammation in ATDC5 cells, as detected by the significant increase in nitric oxide synthase type II activity. The results suggest a range of highly tunable homopolymeric and copolymeric hydrogels as candidates for cartilage regeneration.

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Source
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC10747511PMC
http://dx.doi.org/10.3390/polym15244635DOI Listing

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