AI Article Synopsis
- Type 2 diabetes mellitus (T2D) is a chronic condition marked by insulin resistance and dysfunction of β-cells, leading to various health complications.
- A study analyzed plasma samples from 44 T2D patients and 22 healthy individuals, revealing 229 miRNAs with significant expression differences, including increased levels of miR-5588-5p and decreased levels of miR-496 in T2D patients.
- The researchers also found that obesity affects miRNA expression, specifically miR-144-3p and miR-99a-5p, and identified key pathways related to chromatin modification and apoptosis linked to certain miRNAs.
Article Abstract
Type 2 diabetes mellitus (T2D) is a chronic metabolic disease characterized by insulin resistance and β-cell dysfunction and leading to many micro- and macrovascular complications. In this study we analyzed the circulating miRNA expression profiles in plasma samples from 44 patients with T2D and 22 healthy individuals using next generation sequencing and detected 229 differentially expressed miRNAs. An increased level of miR-5588-5p, miR-125b-2-3p, miR-1284, and a reduced level of miR-496 in T2D patients was verified. We also compared the expression landscapes in the same group of patients depending on body mass index and identified differential expression of miR-144-3p and miR-99a-5p in obese individuals. Identification and functional analysis of putative target genes was performed for miR-5588-5p, miR-125b-2-3p, miR-1284, and miR-496, showing chromatin modifying enzymes and apoptotic genes being among the significantly enriched pathways.
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| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC10744218 | PMC |
| http://dx.doi.org/10.3390/ijms242417406 | DOI Listing |
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